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Synthesis and cytotoxicity assessment of superparamagnetic iron-gold core-shell nanoparticles coated with polyglycerol.
J Colloid Interface Sci. 2010 May 01; 345(1):64-71.JC

Abstract

Core-shell iron-gold (Fe@Au) nanoparticles were synthesized by a facile reverse micelle procedure and the effect of water to surfactant molar ratio (w) on the size, size distribution and magnetic properties of the nanoparticles was studied. MTT assay was utilized to evaluate the cell toxicity of the nanoparticles. To functionalize the particles for MRI imaging and targeted drug delivery, the particles were coated by polyglycerol through capping with thiol followed by polymerization of glycidol. The characteristics of the particles were examined by X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FT-IR). It was found that the size and size distribution of the nanoparticles increase by increasing the water to surfactant molar ratio (w). The particles were spherical in shape with a thin layer of gold. Complementary growth of the gold shell on the iron core was noticed. Meanwhile, two types of agglomeration including magnetic beads and magnetic colloidal nanocrystals clusters were observed dependent on the w-value. The magnetic measurement studies revealed the superparamagnetic behavior of the nanoparticles. MTT assay result indicated the synthesized nanoparticles are nontoxic that will be useful for biomedical applications.

Authors+Show Affiliations

Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11365-9466, Tehran, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20153479

Citation

Jafari, T, et al. "Synthesis and Cytotoxicity Assessment of Superparamagnetic Iron-gold Core-shell Nanoparticles Coated With Polyglycerol." Journal of Colloid and Interface Science, vol. 345, no. 1, 2010, pp. 64-71.
Jafari T, Simchi A, Khakpash N. Synthesis and cytotoxicity assessment of superparamagnetic iron-gold core-shell nanoparticles coated with polyglycerol. J Colloid Interface Sci. 2010;345(1):64-71.
Jafari, T., Simchi, A., & Khakpash, N. (2010). Synthesis and cytotoxicity assessment of superparamagnetic iron-gold core-shell nanoparticles coated with polyglycerol. Journal of Colloid and Interface Science, 345(1), 64-71. https://doi.org/10.1016/j.jcis.2010.01.038
Jafari T, Simchi A, Khakpash N. Synthesis and Cytotoxicity Assessment of Superparamagnetic Iron-gold Core-shell Nanoparticles Coated With Polyglycerol. J Colloid Interface Sci. 2010 May 1;345(1):64-71. PubMed PMID: 20153479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and cytotoxicity assessment of superparamagnetic iron-gold core-shell nanoparticles coated with polyglycerol. AU - Jafari,T, AU - Simchi,A, AU - Khakpash,N, Y1 - 2010/01/18/ PY - 2009/11/10/received PY - 2010/01/10/revised PY - 2010/01/13/accepted PY - 2010/2/16/entrez PY - 2010/2/16/pubmed PY - 2010/6/4/medline SP - 64 EP - 71 JF - Journal of colloid and interface science JO - J Colloid Interface Sci VL - 345 IS - 1 N2 - Core-shell iron-gold (Fe@Au) nanoparticles were synthesized by a facile reverse micelle procedure and the effect of water to surfactant molar ratio (w) on the size, size distribution and magnetic properties of the nanoparticles was studied. MTT assay was utilized to evaluate the cell toxicity of the nanoparticles. To functionalize the particles for MRI imaging and targeted drug delivery, the particles were coated by polyglycerol through capping with thiol followed by polymerization of glycidol. The characteristics of the particles were examined by X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FT-IR). It was found that the size and size distribution of the nanoparticles increase by increasing the water to surfactant molar ratio (w). The particles were spherical in shape with a thin layer of gold. Complementary growth of the gold shell on the iron core was noticed. Meanwhile, two types of agglomeration including magnetic beads and magnetic colloidal nanocrystals clusters were observed dependent on the w-value. The magnetic measurement studies revealed the superparamagnetic behavior of the nanoparticles. MTT assay result indicated the synthesized nanoparticles are nontoxic that will be useful for biomedical applications. SN - 1095-7103 UR - https://www.unboundmedicine.com/medline/citation/20153479/Synthesis_and_cytotoxicity_assessment_of_superparamagnetic_iron_gold_core_shell_nanoparticles_coated_with_polyglycerol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9797(10)00070-6 DB - PRIME DP - Unbound Medicine ER -