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Intramuscular paliperidone palmitate.
CNS Drugs. 2010 Mar; 24(3):227-44.CD

Abstract

Intramuscular paliperidone palmitate is a long-acting, atypical antipsychotic that is indicated in the US for the acute and maintenance therapy of adult patients with schizophrenia. Paliperidone is the major active metabolite of risperidone. The noninferiority of flexible doses of intramuscular paliperidone palmitate 39-156 mg to flexible doses of intramuscular long-acting risperidone 25-50 mg was not established in an initial 53-week study. However, these data were utilized to optimize the intramuscular paliperidone palmitate dosage regimen. In four randomized, double-blind studies, intramuscular paliperidone palmitate 39-234 mg was generally effective in the treatment of adult patients with acute schizophrenia, inducing significantly greater improvements from baseline in the mean Positive and Negative Syndrome Scale (PANSS) total score than placebo (primary endpoint). In general, intramuscular paliperidone palmitate recipients achieved significantly better outcomes than placebo recipients with regard to the PANSS subscale, PANSS factor, Personal and Social Performance scale and Clinical Global Impressions-Severity scale scores. As maintenance therapy, intramuscular paliperidone palmitate 39-156 mg was significantly more effective than placebo in delaying the time to the first relapse of schizophrenia symptoms in adult patients, according to the results of a randomized, double-blind study. The beneficial effects of intramuscular paliperidone palmitate therapy on the PANSS total score were sustained in a 52-week noncomparative extension phase of the maintenance therapy study. Intramuscular paliperidone palmitate 39-234 mg was generally well tolerated in adult patients with schizophrenia.

Authors+Show Affiliations

Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nzNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20155997

Citation

Hoy, Sheridan M., et al. "Intramuscular Paliperidone Palmitate." CNS Drugs, vol. 24, no. 3, 2010, pp. 227-44.
Hoy SM, Scott LJ, Keating GM. Intramuscular paliperidone palmitate. CNS Drugs. 2010;24(3):227-44.
Hoy, S. M., Scott, L. J., & Keating, G. M. (2010). Intramuscular paliperidone palmitate. CNS Drugs, 24(3), 227-44. https://doi.org/10.2165/11203810-000000000-00000
Hoy SM, Scott LJ, Keating GM. Intramuscular Paliperidone Palmitate. CNS Drugs. 2010;24(3):227-44. PubMed PMID: 20155997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intramuscular paliperidone palmitate. AU - Hoy,Sheridan M, AU - Scott,Lesley J, AU - Keating,Gillian M, PY - 2010/2/17/entrez PY - 2010/2/17/pubmed PY - 2010/5/5/medline SP - 227 EP - 44 JF - CNS drugs JO - CNS Drugs VL - 24 IS - 3 N2 - Intramuscular paliperidone palmitate is a long-acting, atypical antipsychotic that is indicated in the US for the acute and maintenance therapy of adult patients with schizophrenia. Paliperidone is the major active metabolite of risperidone. The noninferiority of flexible doses of intramuscular paliperidone palmitate 39-156 mg to flexible doses of intramuscular long-acting risperidone 25-50 mg was not established in an initial 53-week study. However, these data were utilized to optimize the intramuscular paliperidone palmitate dosage regimen. In four randomized, double-blind studies, intramuscular paliperidone palmitate 39-234 mg was generally effective in the treatment of adult patients with acute schizophrenia, inducing significantly greater improvements from baseline in the mean Positive and Negative Syndrome Scale (PANSS) total score than placebo (primary endpoint). In general, intramuscular paliperidone palmitate recipients achieved significantly better outcomes than placebo recipients with regard to the PANSS subscale, PANSS factor, Personal and Social Performance scale and Clinical Global Impressions-Severity scale scores. As maintenance therapy, intramuscular paliperidone palmitate 39-156 mg was significantly more effective than placebo in delaying the time to the first relapse of schizophrenia symptoms in adult patients, according to the results of a randomized, double-blind study. The beneficial effects of intramuscular paliperidone palmitate therapy on the PANSS total score were sustained in a 52-week noncomparative extension phase of the maintenance therapy study. Intramuscular paliperidone palmitate 39-234 mg was generally well tolerated in adult patients with schizophrenia. SN - 1179-1934 UR - https://www.unboundmedicine.com/medline/citation/20155997/Intramuscular_paliperidone_palmitate_ L2 - https://dx.doi.org/10.2165/11203810-000000000-00000 DB - PRIME DP - Unbound Medicine ER -