Tags

Type your tag names separated by a space and hit enter

Metabolic syndrome and angiographic coronary artery disease prevalence in association with the Framingham risk score.
Metab Syndr Relat Disord. 2010 Jun; 8(3):201-8.MS

Abstract

BACKGROUND

The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individual's 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components.

METHODS

We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic syndrome was defined according to the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and the 10-year CAD risk was estimated by the FRS.

RESULTS

Metabolic syndrome patients had a 2-fold higher CAD prevalence compared to those without metabolic syndrome [odds ratio (OR), 2.004; 95% confidence interval (CI), 1.029-3.905] but this finding was attenuated after adjustment for FRS (OR, 1.770; 95% CI, 0.872-3.594). Stratification of patients into three groups according to FRS revealed that metabolic syndrome predictive ability was confined in those being at <10% 10-year CAD risk. Including metabolic syndrome and its individual components into the same logistic regression model, only the glucose criterion was an independent predictor of angiographically significant CAD (OR, 4.137; 95% CI, 1.477-11.583).

CONCLUSIONS

Metabolic syndrome is an independent determinant of angiographically significant CAD only among those individuals at low 10-year risk for future coronary events. Individual components of the syndrome, such as impaired fasting glucose, have a stronger association with CAD than the syndrome as a whole.

Authors+Show Affiliations

First Cardiology Department, AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20156070

Citation

Konstantinou, Dimitris M., et al. "Metabolic Syndrome and Angiographic Coronary Artery Disease Prevalence in Association With the Framingham Risk Score." Metabolic Syndrome and Related Disorders, vol. 8, no. 3, 2010, pp. 201-8.
Konstantinou DM, Chatzizisis YS, Louridas GE, et al. Metabolic syndrome and angiographic coronary artery disease prevalence in association with the Framingham risk score. Metab Syndr Relat Disord. 2010;8(3):201-8.
Konstantinou, D. M., Chatzizisis, Y. S., Louridas, G. E., & Giannoglou, G. D. (2010). Metabolic syndrome and angiographic coronary artery disease prevalence in association with the Framingham risk score. Metabolic Syndrome and Related Disorders, 8(3), 201-8. https://doi.org/10.1089/met.2009.0059
Konstantinou DM, et al. Metabolic Syndrome and Angiographic Coronary Artery Disease Prevalence in Association With the Framingham Risk Score. Metab Syndr Relat Disord. 2010;8(3):201-8. PubMed PMID: 20156070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and angiographic coronary artery disease prevalence in association with the Framingham risk score. AU - Konstantinou,Dimitris M, AU - Chatzizisis,Yiannis S, AU - Louridas,George E, AU - Giannoglou,George D, PY - 2010/2/17/entrez PY - 2010/2/17/pubmed PY - 2010/9/15/medline SP - 201 EP - 8 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 8 IS - 3 N2 - BACKGROUND: The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individual's 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components. METHODS: We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic syndrome was defined according to the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and the 10-year CAD risk was estimated by the FRS. RESULTS: Metabolic syndrome patients had a 2-fold higher CAD prevalence compared to those without metabolic syndrome [odds ratio (OR), 2.004; 95% confidence interval (CI), 1.029-3.905] but this finding was attenuated after adjustment for FRS (OR, 1.770; 95% CI, 0.872-3.594). Stratification of patients into three groups according to FRS revealed that metabolic syndrome predictive ability was confined in those being at <10% 10-year CAD risk. Including metabolic syndrome and its individual components into the same logistic regression model, only the glucose criterion was an independent predictor of angiographically significant CAD (OR, 4.137; 95% CI, 1.477-11.583). CONCLUSIONS: Metabolic syndrome is an independent determinant of angiographically significant CAD only among those individuals at low 10-year risk for future coronary events. Individual components of the syndrome, such as impaired fasting glucose, have a stronger association with CAD than the syndrome as a whole. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/20156070/Metabolic_syndrome_and_angiographic_coronary_artery_disease_prevalence_in_association_with_the_Framingham_risk_score_ L2 - https://www.liebertpub.com/doi/10.1089/met.2009.0059?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -