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Increased risk of low birthweight and small for gestational age infants among women with tuberculosis.
BJOG. 2010 Apr; 117(5):585-90.BJOG

Abstract

OBJECTIVE

As the relationship between tuberculosis (TB) and fetal outcomes remains unclear, this study used a 3-year nationwide population-based data set to determine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth and small for gestational age (SGA) infants] among women with TB.

DESIGN

A cross-sectional retrospective study.

SETTING

Taiwan.

SAMPLE

Linking the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset, we identified 761 women who gave birth from 2001 to 2003 and who had received medication treatment for TB during their pregnancy, together with 3805 unaffected women matched in terms of age and year of delivery.

METHODS

Conditional logistic regression analyses were performed to compare the risk of LBW, preterm birth and SGA for mothers with TB and unaffected mothers.

MAIN OUTCOME MEASURES

The risk of LBW, preterm birth and SGA.

RESULTS

Mothers diagnosed with TB had significantly higher percentages of LBW (8.5 versus 6.4%, P = 0.033) and SGA (19.7 versus 16.7%, P = 0.048) infants than unaffected mothers. However, there was no significant difference in preterm birth (8.0 versus 8.0%, P = 0.961) between these two groups. The adjusted odds ratios of having LBW and SGA infants for mothers with TB were 1.35 (95% CI = 1.01-1.81) and 1.22 (95% CI = 1.00-1.49), respectively, compared with unaffected mothers.

CONCLUSIONS

We concluded that women diagnosed with TB during pregnancy are at increased risk for having LBW and SGA babies, compared with unaffected mothers. We suggest that clinicians should make women with TB aware of the potential risks before planning a child.

Authors+Show Affiliations

School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

20156210

Citation

Lin, H-C, et al. "Increased Risk of Low Birthweight and Small for Gestational Age Infants Among Women With Tuberculosis." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 117, no. 5, 2010, pp. 585-90.
Lin HC, Lin HC, Chen SF. Increased risk of low birthweight and small for gestational age infants among women with tuberculosis. BJOG. 2010;117(5):585-90.
Lin, H. C., Lin, H. C., & Chen, S. F. (2010). Increased risk of low birthweight and small for gestational age infants among women with tuberculosis. BJOG : an International Journal of Obstetrics and Gynaecology, 117(5), 585-90. https://doi.org/10.1111/j.1471-0528.2010.02504.x
Lin HC, Lin HC, Chen SF. Increased Risk of Low Birthweight and Small for Gestational Age Infants Among Women With Tuberculosis. BJOG. 2010;117(5):585-90. PubMed PMID: 20156210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of low birthweight and small for gestational age infants among women with tuberculosis. AU - Lin,H-C, AU - Lin,H-C, AU - Chen,S-F, Y1 - 2010/02/15/ PY - 2010/2/17/entrez PY - 2010/2/17/pubmed PY - 2010/6/9/medline SP - 585 EP - 90 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 117 IS - 5 N2 - OBJECTIVE: As the relationship between tuberculosis (TB) and fetal outcomes remains unclear, this study used a 3-year nationwide population-based data set to determine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth and small for gestational age (SGA) infants] among women with TB. DESIGN: A cross-sectional retrospective study. SETTING: Taiwan. SAMPLE: Linking the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset, we identified 761 women who gave birth from 2001 to 2003 and who had received medication treatment for TB during their pregnancy, together with 3805 unaffected women matched in terms of age and year of delivery. METHODS: Conditional logistic regression analyses were performed to compare the risk of LBW, preterm birth and SGA for mothers with TB and unaffected mothers. MAIN OUTCOME MEASURES: The risk of LBW, preterm birth and SGA. RESULTS: Mothers diagnosed with TB had significantly higher percentages of LBW (8.5 versus 6.4%, P = 0.033) and SGA (19.7 versus 16.7%, P = 0.048) infants than unaffected mothers. However, there was no significant difference in preterm birth (8.0 versus 8.0%, P = 0.961) between these two groups. The adjusted odds ratios of having LBW and SGA infants for mothers with TB were 1.35 (95% CI = 1.01-1.81) and 1.22 (95% CI = 1.00-1.49), respectively, compared with unaffected mothers. CONCLUSIONS: We concluded that women diagnosed with TB during pregnancy are at increased risk for having LBW and SGA babies, compared with unaffected mothers. We suggest that clinicians should make women with TB aware of the potential risks before planning a child. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/20156210/Increased_risk_of_low_birthweight_and_small_for_gestational_age_infants_among_women_with_tuberculosis_ L2 - https://doi.org/10.1111/j.1471-0528.2010.02504.x DB - PRIME DP - Unbound Medicine ER -