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Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain.
Proc Nutr Soc. 2010 May; 69(2):244-60.PN

Abstract

The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance. Flavonoids mediate these effects via a number of routes, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning and cognitive function. Originally, it was thought that such actions were mediated by the antioxidant capacity of flavonoids. However, their limited absorption and their low bioavailability in the brain suggest that this explanation is unlikely. Instead, this multiplicity of effects appears to be underpinned by three separate processes: first, through their interactions with important neuronal and glial signalling cascades in the brain, most notably the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways that regulate pro-survival transcription factors and gene expression; second, through an ability to improve peripheral and cerebral blood flow and to trigger angiogenesis and neurogenesis in the hippocampus; third, by their capacity to directly react with and scavenge neurotoxic species and pro-inflammatory agents produced in the brain as a result of both normal and abnormal brain ageing. The present review explores the potential inhibitory or stimulatory actions of flavonoids within these three systems and describes how such interactions are likely to underlie neurological effects.

Authors+Show Affiliations

Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK. j.p.e.spencer@reading.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20158941

Citation

Spencer, Jeremy P E.. "Beyond Antioxidants: the Cellular and Molecular Interactions of Flavonoids and How These Underpin Their Actions On the Brain." The Proceedings of the Nutrition Society, vol. 69, no. 2, 2010, pp. 244-60.
Spencer JP. Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proc Nutr Soc. 2010;69(2):244-60.
Spencer, J. P. (2010). Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. The Proceedings of the Nutrition Society, 69(2), 244-60. https://doi.org/10.1017/S0029665110000054
Spencer JP. Beyond Antioxidants: the Cellular and Molecular Interactions of Flavonoids and How These Underpin Their Actions On the Brain. Proc Nutr Soc. 2010;69(2):244-60. PubMed PMID: 20158941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. A1 - Spencer,Jeremy P E, Y1 - 2010/02/17/ PY - 2010/2/18/entrez PY - 2010/2/18/pubmed PY - 2010/8/13/medline SP - 244 EP - 60 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 69 IS - 2 N2 - The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance. Flavonoids mediate these effects via a number of routes, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning and cognitive function. Originally, it was thought that such actions were mediated by the antioxidant capacity of flavonoids. However, their limited absorption and their low bioavailability in the brain suggest that this explanation is unlikely. Instead, this multiplicity of effects appears to be underpinned by three separate processes: first, through their interactions with important neuronal and glial signalling cascades in the brain, most notably the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways that regulate pro-survival transcription factors and gene expression; second, through an ability to improve peripheral and cerebral blood flow and to trigger angiogenesis and neurogenesis in the hippocampus; third, by their capacity to directly react with and scavenge neurotoxic species and pro-inflammatory agents produced in the brain as a result of both normal and abnormal brain ageing. The present review explores the potential inhibitory or stimulatory actions of flavonoids within these three systems and describes how such interactions are likely to underlie neurological effects. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/20158941/Beyond_antioxidants:_the_cellular_and_molecular_interactions_of_flavonoids_and_how_these_underpin_their_actions_on_the_brain_ L2 - https://www.cambridge.org/core/product/identifier/S0029665110000054/type/journal_article DB - PRIME DP - Unbound Medicine ER -