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Liver disease in pregnancy.
Lancet. 2010 Feb 13; 375(9714):594-605.Lct

Abstract

Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal survival. A rapid diagnosis differentiating between liver disease related and unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. Research has improved our understanding of the pathogenesis of pregnancy-related liver disease, which has translated into improved maternal and fetal outcomes. Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options.

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Authors+Show Affiliations

Joshi D
Institute of Liver Studies, King's College Hospital, London, UK.
James A
No affiliation info available
Quaglia A
No affiliation info available
Westbrook RH
No affiliation info available
Heneghan MA
No affiliation info available

MeSH

Cholestasis, IntrahepaticEclampsiaFatty LiverFemaleHELLP SyndromeHumansHyperemesis GravidarumLiver DiseasesLiver TransplantationPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy OutcomePrognosisRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20159293

Citation

Joshi, Deepak, et al. "Liver Disease in Pregnancy." Lancet (London, England), vol. 375, no. 9714, 2010, pp. 594-605.
Joshi D, James A, Quaglia A, et al. Liver disease in pregnancy. Lancet. 2010;375(9714):594-605.
Joshi, D., James, A., Quaglia, A., Westbrook, R. H., & Heneghan, M. A. (2010). Liver disease in pregnancy. Lancet (London, England), 375(9714), 594-605. https://doi.org/10.1016/S0140-6736(09)61495-1
Joshi D, et al. Liver Disease in Pregnancy. Lancet. 2010 Feb 13;375(9714):594-605. PubMed PMID: 20159293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver disease in pregnancy. AU - Joshi,Deepak, AU - James,Andra, AU - Quaglia,Alberto, AU - Westbrook,Rachel H, AU - Heneghan,Michael A, PY - 2010/2/18/entrez PY - 2010/2/18/pubmed PY - 2010/3/10/medline SP - 594 EP - 605 JF - Lancet (London, England) JO - Lancet VL - 375 IS - 9714 N2 - Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal survival. A rapid diagnosis differentiating between liver disease related and unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. Research has improved our understanding of the pathogenesis of pregnancy-related liver disease, which has translated into improved maternal and fetal outcomes. Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/20159293/Liver_disease_in_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(09)61495-1 DB - PRIME DP - Unbound Medicine ER -