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Evaluation of zeta-potential and particle size of technetium 99mTc-sulfur colloid subsequent to the addition of lidocaine and sodium bicarbonate.
J Nucl Med Technol. 2010 Mar; 38(1):49-52.JN

Abstract

The use of (99m)Tc-sulfur colloid lymphoscintigraphy for the determination of lymph flow patterns from a tumor site and localization of the sentinel node has been widely adopted. However, the effects of multiple injections of the radiopharmaceutical can range from mild discomfort to pain. pH-adjusted lidocaine HCl coadministered with (99m)Tc-sulfur colloid presents a risk of introducing instability of the radiopharmaceutical, which could lead to aggregation, possibly impeding the kinetics of lymphatic drainage from the tumor site.

METHODS

In the present study, lidocaine pH-adjusted with 4.2%, 6.3%, or 8.4% sodium bicarbonate was added to the (99m)Tc-sulfur colloid radiopharmaceutical to monitor effects on radiochemical purity, zeta-potential, particle size, and pH. These parameters were then used to evaluate the short-term stability of the preparation.

RESULTS

The study revealed that the formulation of lidocaine pH-adjusted with 8.4% sodium bicarbonate added to (99m)Tc-sulfur colloid demonstrated a similar change in zeta-potential (-4.09 +/- 2.90 mV) and particle size (10-330 nm) to that of control filtered (99m)Tc-sulfur colloid (-5.09 +/- 1.68 mV and 11-343 nm, respectively). However, the 4.2% preparation showed a zeta-potential of -3.01 +/- 2.24 mV and a particle size range of 10-351 nm. The pH of the 8.4% buffered preparation, at 7.1, was closer to physiologic pH than was the control, at 6.0. The 6.3% pH-adjusted lidocaine-(99m)Tc-sulfur colloid preparation failed radiochemical purity; thus, it was not included in the analysis.

CONCLUSION

Compared with other (99m)Tc-sulfur colloid test formulations of 4.2% and 6.3% pH-adjusted lidocaine, the 8.4% sodium bicarbonate pH-adjusted lidocaine-(99m)Tc-sulfur colloid preparation, taken as a whole, yielded superior quality-control parameters. This formulation would be an acceptable alternative to the control.

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Authors+Show Affiliations

Loveless VS
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center-Memphis, Memphis, Tennessee, USA. vloveless@utmem.edu
Surdock CP
No affiliation info available
Bhattacharjee H
No affiliation info available

MeSH

HumansHydrogen-Ion ConcentrationLidocaineParticle SizeSodium BicarbonateTechnetium Tc 99m Sulfur Colloid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20159927

Citation

Loveless, Vivian S., et al. "Evaluation of Zeta-potential and Particle Size of Technetium 99mTc-sulfur Colloid Subsequent to the Addition of Lidocaine and Sodium Bicarbonate." Journal of Nuclear Medicine Technology, vol. 38, no. 1, 2010, pp. 49-52.
Loveless VS, Surdock CP, Bhattacharjee H. Evaluation of zeta-potential and particle size of technetium 99mTc-sulfur colloid subsequent to the addition of lidocaine and sodium bicarbonate. J Nucl Med Technol. 2010;38(1):49-52.
Loveless, V. S., Surdock, C. P., & Bhattacharjee, H. (2010). Evaluation of zeta-potential and particle size of technetium 99mTc-sulfur colloid subsequent to the addition of lidocaine and sodium bicarbonate. Journal of Nuclear Medicine Technology, 38(1), 49-52. https://doi.org/10.2967/jnmt.109.068973
Loveless VS, Surdock CP, Bhattacharjee H. Evaluation of Zeta-potential and Particle Size of Technetium 99mTc-sulfur Colloid Subsequent to the Addition of Lidocaine and Sodium Bicarbonate. J Nucl Med Technol. 2010;38(1):49-52. PubMed PMID: 20159927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of zeta-potential and particle size of technetium 99mTc-sulfur colloid subsequent to the addition of lidocaine and sodium bicarbonate. AU - Loveless,Vivian S, AU - Surdock,Christopher P, AU - Bhattacharjee,Himanshu, Y1 - 2010/02/16/ PY - 2010/2/18/entrez PY - 2010/2/18/pubmed PY - 2010/9/21/medline SP - 49 EP - 52 JF - Journal of nuclear medicine technology JO - J Nucl Med Technol VL - 38 IS - 1 N2 - UNLABELLED: The use of (99m)Tc-sulfur colloid lymphoscintigraphy for the determination of lymph flow patterns from a tumor site and localization of the sentinel node has been widely adopted. However, the effects of multiple injections of the radiopharmaceutical can range from mild discomfort to pain. pH-adjusted lidocaine HCl coadministered with (99m)Tc-sulfur colloid presents a risk of introducing instability of the radiopharmaceutical, which could lead to aggregation, possibly impeding the kinetics of lymphatic drainage from the tumor site. METHODS: In the present study, lidocaine pH-adjusted with 4.2%, 6.3%, or 8.4% sodium bicarbonate was added to the (99m)Tc-sulfur colloid radiopharmaceutical to monitor effects on radiochemical purity, zeta-potential, particle size, and pH. These parameters were then used to evaluate the short-term stability of the preparation. RESULTS: The study revealed that the formulation of lidocaine pH-adjusted with 8.4% sodium bicarbonate added to (99m)Tc-sulfur colloid demonstrated a similar change in zeta-potential (-4.09 +/- 2.90 mV) and particle size (10-330 nm) to that of control filtered (99m)Tc-sulfur colloid (-5.09 +/- 1.68 mV and 11-343 nm, respectively). However, the 4.2% preparation showed a zeta-potential of -3.01 +/- 2.24 mV and a particle size range of 10-351 nm. The pH of the 8.4% buffered preparation, at 7.1, was closer to physiologic pH than was the control, at 6.0. The 6.3% pH-adjusted lidocaine-(99m)Tc-sulfur colloid preparation failed radiochemical purity; thus, it was not included in the analysis. CONCLUSION: Compared with other (99m)Tc-sulfur colloid test formulations of 4.2% and 6.3% pH-adjusted lidocaine, the 8.4% sodium bicarbonate pH-adjusted lidocaine-(99m)Tc-sulfur colloid preparation, taken as a whole, yielded superior quality-control parameters. This formulation would be an acceptable alternative to the control. SN - 1535-5675 UR - https://www.unboundmedicine.com/medline/citation/20159927/Evaluation_of_zeta_potential_and_particle_size_of_technetium_99mTc_sulfur_colloid_subsequent_to_the_addition_of_lidocaine_and_sodium_bicarbonate_ L2 - http://tech.snmjournals.org/cgi/pmidlookup?view=long&pmid=20159927 DB - PRIME DP - Unbound Medicine ER -