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Choline and betaine intake and the risk of colorectal cancer in men.

Abstract

Dietary choline and betaine have been hypothesized to decrease the risk of cancer because of their role as methyl donors in the one-carbon metabolism. However, it remains unknown whether dietary intake of choline and betaine is associated with colorectal cancer risk. We prospectively examined the associations between dietary choline and betaine intake and risk of colorectal cancer in men in the Health Professionals Follow-up Study. We followed 47,302 men and identified a total of 987 incident colorectal cancer cases from 1986 to 2004. We assessed dietary and supplemental choline and betaine intake every 4 years using a validated semiquantitative food frequency questionnaire. The Cox proportional hazards model was used to estimate multivariate relative risks and 95% confidence intervals. All statistical tests were two-sided. We did not find any statistically significant associations between choline intake or betaine intake and risk of colorectal cancer. Comparing the top quintile with bottom quintile, multivariate relative risks (95% confidence interval) were 0.97 (0.79-1.20; P(trend) = 0.87) for choline intake and 0.94 (0.77-1.16; P(trend) = 0.79) for betaine intake. Similarly, we observed no associations between colorectal cancer risk and choline from free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine, or sphingomyelin. Our data do not support the hypothesis that choline and betaine intake is inversely associated with colorectal cancer risk.

Authors+Show Affiliations

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. jung.lee@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20160273

Citation

Lee, Jung Eun, et al. "Choline and Betaine Intake and the Risk of Colorectal Cancer in Men." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 19, no. 3, 2010, pp. 884-7.
Lee JE, Giovannucci E, Fuchs CS, et al. Choline and betaine intake and the risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev. 2010;19(3):884-7.
Lee, J. E., Giovannucci, E., Fuchs, C. S., Willett, W. C., Zeisel, S. H., & Cho, E. (2010). Choline and betaine intake and the risk of colorectal cancer in men. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 19(3), pp. 884-7. doi:10.1158/1055-9965.EPI-09-1295.
Lee JE, et al. Choline and Betaine Intake and the Risk of Colorectal Cancer in Men. Cancer Epidemiol Biomarkers Prev. 2010;19(3):884-7. PubMed PMID: 20160273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Choline and betaine intake and the risk of colorectal cancer in men. AU - Lee,Jung Eun, AU - Giovannucci,Edward, AU - Fuchs,Charles S, AU - Willett,Walter C, AU - Zeisel,Steven H, AU - Cho,Eunyoung, Y1 - 2010/02/16/ PY - 2010/2/18/entrez PY - 2010/2/18/pubmed PY - 2010/6/15/medline SP - 884 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 19 IS - 3 N2 - Dietary choline and betaine have been hypothesized to decrease the risk of cancer because of their role as methyl donors in the one-carbon metabolism. However, it remains unknown whether dietary intake of choline and betaine is associated with colorectal cancer risk. We prospectively examined the associations between dietary choline and betaine intake and risk of colorectal cancer in men in the Health Professionals Follow-up Study. We followed 47,302 men and identified a total of 987 incident colorectal cancer cases from 1986 to 2004. We assessed dietary and supplemental choline and betaine intake every 4 years using a validated semiquantitative food frequency questionnaire. The Cox proportional hazards model was used to estimate multivariate relative risks and 95% confidence intervals. All statistical tests were two-sided. We did not find any statistically significant associations between choline intake or betaine intake and risk of colorectal cancer. Comparing the top quintile with bottom quintile, multivariate relative risks (95% confidence interval) were 0.97 (0.79-1.20; P(trend) = 0.87) for choline intake and 0.94 (0.77-1.16; P(trend) = 0.79) for betaine intake. Similarly, we observed no associations between colorectal cancer risk and choline from free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine, or sphingomyelin. Our data do not support the hypothesis that choline and betaine intake is inversely associated with colorectal cancer risk. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/20160273/Choline_and_betaine_intake_and_the_risk_of_colorectal_cancer_in_men_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20160273 DB - PRIME DP - Unbound Medicine ER -