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[Do obstetric complications increase the risk of schizophrenia?].
Tidsskr Nor Laegeforen 2010; 130(3):270-2TN

Abstract

BACKGROUND

Schizophrenia is a serious mental disease of unknown aetiology. Genetic liability is the most important risk factor. Several studies have demonstrated that pre and perinatal complications/traumas are associated with an increased risk of developing schizophrenia in adult age. The purpose of this article is to provide an overview of research on obstetric complications as risk factors for schizophrenia.

MATERIAL AND METHODS

The article is based on literature identified through non-systematic searches in the databases PubMed and Embase.

RESULTS

The putative association between obstetric complications and schizophrenia has been investigated for almost 80 years. Numerous controlled studies have found that maternal infection (influenza, rubella, toxoplasmosis), prenatal malnutrition and birth-associated complications (such as low birth weight and asphyxia) are associated with an increased risk of developing schizophrenia. Experiments in animal models suggest that foetal hypoxia and maternal inflammatory responses may affect neuronal development. However, underlying pathophysiological mechanisms and modes of interaction with schizophrenia susceptibility genes are unknown.

INTERPRETATION

An association between obstetric complications and an increased risk of schizophrenia is strongly supported by scientific evidence.

Authors+Show Affiliations

Institutt for psykiatri, Universitetet i Oslo, Postboks 85 Vinderen, 0319 Oslo, Norway. unn.haukvik@medisin.uio.noNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

nor

PubMed ID

20160770

Citation

Haukvik, Unn Kristin, and Ingrid Agartz. "[Do Obstetric Complications Increase the Risk of Schizophrenia?]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 130, no. 3, 2010, pp. 270-2.
Haukvik UK, Agartz I. [Do obstetric complications increase the risk of schizophrenia?]. Tidsskr Nor Laegeforen. 2010;130(3):270-2.
Haukvik, U. K., & Agartz, I. (2010). [Do obstetric complications increase the risk of schizophrenia?]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 130(3), pp. 270-2. doi:10.4045/tidsskr.09.0699.
Haukvik UK, Agartz I. [Do Obstetric Complications Increase the Risk of Schizophrenia?]. Tidsskr Nor Laegeforen. 2010 Feb 11;130(3):270-2. PubMed PMID: 20160770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Do obstetric complications increase the risk of schizophrenia?]. AU - Haukvik,Unn Kristin, AU - Agartz,Ingrid, PY - 2010/2/18/entrez PY - 2010/2/18/pubmed PY - 2010/3/4/medline SP - 270 EP - 2 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr. Nor. Laegeforen. VL - 130 IS - 3 N2 - BACKGROUND: Schizophrenia is a serious mental disease of unknown aetiology. Genetic liability is the most important risk factor. Several studies have demonstrated that pre and perinatal complications/traumas are associated with an increased risk of developing schizophrenia in adult age. The purpose of this article is to provide an overview of research on obstetric complications as risk factors for schizophrenia. MATERIAL AND METHODS: The article is based on literature identified through non-systematic searches in the databases PubMed and Embase. RESULTS: The putative association between obstetric complications and schizophrenia has been investigated for almost 80 years. Numerous controlled studies have found that maternal infection (influenza, rubella, toxoplasmosis), prenatal malnutrition and birth-associated complications (such as low birth weight and asphyxia) are associated with an increased risk of developing schizophrenia. Experiments in animal models suggest that foetal hypoxia and maternal inflammatory responses may affect neuronal development. However, underlying pathophysiological mechanisms and modes of interaction with schizophrenia susceptibility genes are unknown. INTERPRETATION: An association between obstetric complications and an increased risk of schizophrenia is strongly supported by scientific evidence. SN - 0807-7096 UR - https://www.unboundmedicine.com/medline/citation/20160770/[Do_obstetric_complications_increase_the_risk_of_schizophrenia]_ L2 - http://tidsskriftet.no/article/1943454 DB - PRIME DP - Unbound Medicine ER -