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Interactions between cadmium and zinc in the biological samples of Pakistani smokers and nonsmokers cardiovascular disease patients.
Biol Trace Elem Res. 2011 Mar; 139(3):257-68.BT

Abstract

The pathogenesis of some cardiovascular diseases (CVDs) has been altered with changes in the balance of certain trace and toxic elements. The aim of the present study was to assess the role of zinc (Zn) and cadmium (Cd) in smoker and nonsmoker male CVD patients (n = 457) of two age groups (31-45) and (46-60). The both elements were determined in biological samples (scalp hair, blood, and urine) of CVD patients and healthy referents for comparison purpose. The concentrations of Zn and Cd were measured by atomic absorption spectrophotometer prior to microwave-assisted acid digestion. It was observed that the mean values of Cd were significantly higher in the biological samples of smokers CVD as compared to nonsmoker CVD patients, while the level of Zn was lower in both smoker and nonsmoker patients. The concentrations of Zn in whole blood and scalp hair samples were lower in CVD patients as compared to referents (p > 0.001). Results showed significant changes of levels of Cd and Zn in blood and scalp hair samples of CVD patients when compared with healthy referents, while reverse in the case of urine samples. It was observed that low Zn levels were associated with both smoker and nonsmoker CVD patients, while increased cadmium accumulation was observed in smoker patients as compared to nonsmoker patients (p > 0.025).

Authors+Show Affiliations

National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20162377

Citation

Afridi, Hassan Imran, et al. "Interactions Between Cadmium and Zinc in the Biological Samples of Pakistani Smokers and Nonsmokers Cardiovascular Disease Patients." Biological Trace Element Research, vol. 139, no. 3, 2011, pp. 257-68.
Afridi HI, Kazi TG, Kazi N, et al. Interactions between cadmium and zinc in the biological samples of Pakistani smokers and nonsmokers cardiovascular disease patients. Biol Trace Elem Res. 2011;139(3):257-68.
Afridi, H. I., Kazi, T. G., Kazi, N., Kandhro, G. A., Baig, J. A., Jamali, M. K., Arain, M. B., & Shah, A. Q. (2011). Interactions between cadmium and zinc in the biological samples of Pakistani smokers and nonsmokers cardiovascular disease patients. Biological Trace Element Research, 139(3), 257-68. https://doi.org/10.1007/s12011-009-8607-3
Afridi HI, et al. Interactions Between Cadmium and Zinc in the Biological Samples of Pakistani Smokers and Nonsmokers Cardiovascular Disease Patients. Biol Trace Elem Res. 2011;139(3):257-68. PubMed PMID: 20162377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions between cadmium and zinc in the biological samples of Pakistani smokers and nonsmokers cardiovascular disease patients. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Kazi,Naveed, AU - Kandhro,Ghulam Abbas, AU - Baig,Jameel Ahmed, AU - Jamali,Mohammad Khan, AU - Arain,Mohammad Balal, AU - Shah,Abdul Qadir, Y1 - 2010/02/17/ PY - 2009/11/04/received PY - 2009/12/28/accepted PY - 2010/2/18/entrez PY - 2010/2/18/pubmed PY - 2011/5/17/medline SP - 257 EP - 68 JF - Biological trace element research JO - Biol Trace Elem Res VL - 139 IS - 3 N2 - The pathogenesis of some cardiovascular diseases (CVDs) has been altered with changes in the balance of certain trace and toxic elements. The aim of the present study was to assess the role of zinc (Zn) and cadmium (Cd) in smoker and nonsmoker male CVD patients (n = 457) of two age groups (31-45) and (46-60). The both elements were determined in biological samples (scalp hair, blood, and urine) of CVD patients and healthy referents for comparison purpose. The concentrations of Zn and Cd were measured by atomic absorption spectrophotometer prior to microwave-assisted acid digestion. It was observed that the mean values of Cd were significantly higher in the biological samples of smokers CVD as compared to nonsmoker CVD patients, while the level of Zn was lower in both smoker and nonsmoker patients. The concentrations of Zn in whole blood and scalp hair samples were lower in CVD patients as compared to referents (p > 0.001). Results showed significant changes of levels of Cd and Zn in blood and scalp hair samples of CVD patients when compared with healthy referents, while reverse in the case of urine samples. It was observed that low Zn levels were associated with both smoker and nonsmoker CVD patients, while increased cadmium accumulation was observed in smoker patients as compared to nonsmoker patients (p > 0.025). SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/20162377/Interactions_between_cadmium_and_zinc_in_the_biological_samples_of_Pakistani_smokers_and_nonsmokers_cardiovascular_disease_patients_ L2 - https://dx.doi.org/10.1007/s12011-009-8607-3 DB - PRIME DP - Unbound Medicine ER -