Tags

Type your tag names separated by a space and hit enter

Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose.
Arch Pharm Res. 2009 Dec; 32(12):1767-74.AP

Abstract

Using mixture experimental design, the effect of carbomer (Carbopol((R)) 971P NF) and hydroxypropylmethylcellulose (Methocel((R)) K100M or Methocel((R)) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.

Authors+Show Affiliations

Galenika a.d., Institute for Research and Development, Batajnicki drum b.b, Belgrade, Serbia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20162406

Citation

Petrovic, Aleksandra, et al. "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxy-propylmethylcellulose." Archives of Pharmacal Research, vol. 32, no. 12, 2009, pp. 1767-74.
Petrovic A, Cvetkovic N, Ibric S, et al. Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose. Arch Pharm Res. 2009;32(12):1767-74.
Petrovic, A., Cvetkovic, N., Ibric, S., Trajkovic, S., Djuric, Z., Popadic, D., & Popovic, R. (2009). Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose. Archives of Pharmacal Research, 32(12), 1767-74. https://doi.org/10.1007/s12272-009-2215-9
Petrovic A, et al. Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxy-propylmethylcellulose. Arch Pharm Res. 2009;32(12):1767-74. PubMed PMID: 20162406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose. AU - Petrovic,Aleksandra, AU - Cvetkovic,Nebojsa, AU - Ibric,Svetlana, AU - Trajkovic,Svetlana, AU - Djuric,Zorica, AU - Popadic,Dragica, AU - Popovic,Radmila, Y1 - 2010/02/17/ PY - 2009/06/11/received PY - 2009/09/15/accepted PY - 2009/09/07/revised PY - 2010/2/18/entrez PY - 2010/2/18/pubmed PY - 2010/5/19/medline SP - 1767 EP - 74 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 32 IS - 12 N2 - Using mixture experimental design, the effect of carbomer (Carbopol((R)) 971P NF) and hydroxypropylmethylcellulose (Methocel((R)) K100M or Methocel((R)) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/20162406/Application_of_mixture_experimental_design_in_the_formulation_and_optimization_of_matrix_tablets_containing_carbomer_and_hydroxy_propylmethylcellulose_ DB - PRIME DP - Unbound Medicine ER -