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Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study.
Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3399-404.IO

Abstract

PURPOSE.

To describe the distribution of ocular perfusion pressure and its relationship with open-angle glaucoma (OAG) in a Malay population.

METHODS.

This was a population-based, cross-sectional study comprising 3280 (78.7% response) ethnic Malays. Intraocular pressure (IOP) was measured with Goldmann applanation tonometry. Systolic and diastolic blood pressure (SBP and DBP) was measured with a digital automatic blood pressure monitor. Mean ocular perfusion pressure (MOPP) = (2/3)(mean arterial pressure - IOP), where mean arterial pressure (MAP) = DBP + (1/3)(SBP - DBP), systolic perfusion pressure (SPP) = SBP - IOP, and diastolic perfusion pressure (DPP) = DBP - IOP, was calculated. The diagnosis of OAG was based on International Society for Geographical and Epidemiologic Ophthalmology criteria.

RESULTS.

A total of 3261 persons (mean age, 58.7 +/- 11 years, including 131 [4.0%] cases of OAG) were available for analyses. Among persons without glaucoma, the mean +/- SD IOP, MOPP, SPP, and DPP were 15.3 +/- 3.5, 52.8 +/- 9.3, 131.5 +/- 23.3, and 64.5 +/- 11.3 mm Hg, respectively. Among persons with OAG, the corresponding values were 16.8 +/- 5.9, 51.6 +/- 10.2, 134.5 +/- 24.6, and 61.4 +/- 11.5 mm Hg, respectively. In multiple logistic regression models adjusting for IOP, age, sex, and IOP- and BP-lowering treatments, OAG risk was significantly higher in participants with DBP, MOPP, or DPP in the lowest quartile (Q1) than in participants in the highest quartile (Q4) (Q1 vs. Q4: odds ratio [OR], 1.71 [95% confidence interval (CI), 1.04-2.96] for DBP; OR, 1.73 [95% CI, 1.05-3.15] for MOPP; OR, 1.75 [95% CI, 1.02-3.01] for DPP).

CONCLUSIONS.

Low DBP, low MOPP, and low DPP are independent risk factors for OAG in ethnic Malays, providing further evidence of a vascular mechanism in glaucoma pathogenesis across different populations.

Authors+Show Affiliations

Singapore Eye Research Institute, Singapore National Eye Center, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20164462

Citation

Zheng, Yingfeng, et al. "Distribution of Ocular Perfusion Pressure and Its Relationship With Open-angle Glaucoma: the Singapore Malay Eye Study." Investigative Ophthalmology & Visual Science, vol. 51, no. 7, 2010, pp. 3399-404.
Zheng Y, Wong TY, Mitchell P, et al. Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study. Invest Ophthalmol Vis Sci. 2010;51(7):3399-404.
Zheng, Y., Wong, T. Y., Mitchell, P., Friedman, D. S., He, M., & Aung, T. (2010). Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study. Investigative Ophthalmology & Visual Science, 51(7), 3399-404. https://doi.org/10.1167/iovs.09-4867
Zheng Y, et al. Distribution of Ocular Perfusion Pressure and Its Relationship With Open-angle Glaucoma: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci. 2010;51(7):3399-404. PubMed PMID: 20164462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study. AU - Zheng,Yingfeng, AU - Wong,Tien Y, AU - Mitchell,Paul, AU - Friedman,David S, AU - He,Mingguang, AU - Aung,Tin, Y1 - 2010/02/17/ PY - 2010/2/19/entrez PY - 2010/2/19/pubmed PY - 2010/8/3/medline SP - 3399 EP - 404 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 51 IS - 7 N2 - PURPOSE. To describe the distribution of ocular perfusion pressure and its relationship with open-angle glaucoma (OAG) in a Malay population. METHODS. This was a population-based, cross-sectional study comprising 3280 (78.7% response) ethnic Malays. Intraocular pressure (IOP) was measured with Goldmann applanation tonometry. Systolic and diastolic blood pressure (SBP and DBP) was measured with a digital automatic blood pressure monitor. Mean ocular perfusion pressure (MOPP) = (2/3)(mean arterial pressure - IOP), where mean arterial pressure (MAP) = DBP + (1/3)(SBP - DBP), systolic perfusion pressure (SPP) = SBP - IOP, and diastolic perfusion pressure (DPP) = DBP - IOP, was calculated. The diagnosis of OAG was based on International Society for Geographical and Epidemiologic Ophthalmology criteria. RESULTS. A total of 3261 persons (mean age, 58.7 +/- 11 years, including 131 [4.0%] cases of OAG) were available for analyses. Among persons without glaucoma, the mean +/- SD IOP, MOPP, SPP, and DPP were 15.3 +/- 3.5, 52.8 +/- 9.3, 131.5 +/- 23.3, and 64.5 +/- 11.3 mm Hg, respectively. Among persons with OAG, the corresponding values were 16.8 +/- 5.9, 51.6 +/- 10.2, 134.5 +/- 24.6, and 61.4 +/- 11.5 mm Hg, respectively. In multiple logistic regression models adjusting for IOP, age, sex, and IOP- and BP-lowering treatments, OAG risk was significantly higher in participants with DBP, MOPP, or DPP in the lowest quartile (Q1) than in participants in the highest quartile (Q4) (Q1 vs. Q4: odds ratio [OR], 1.71 [95% confidence interval (CI), 1.04-2.96] for DBP; OR, 1.73 [95% CI, 1.05-3.15] for MOPP; OR, 1.75 [95% CI, 1.02-3.01] for DPP). CONCLUSIONS. Low DBP, low MOPP, and low DPP are independent risk factors for OAG in ethnic Malays, providing further evidence of a vascular mechanism in glaucoma pathogenesis across different populations. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/20164462/Distribution_of_ocular_perfusion_pressure_and_its_relationship_with_open_angle_glaucoma:_the_singapore_malay_eye_study_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.09-4867 DB - PRIME DP - Unbound Medicine ER -