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Caffeine and adenosine.
J Alzheimers Dis. 2010; 20 Suppl 1:S3-15.JA

Abstract

Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of endogenous adenosinergic tonus. Besides AR antagonism, xanthines, including caffeine, have other biological actions: they inhibit phosphodiesterases (PDEs) (e.g., PDE1, PDE4, PDE5), promote calcium release from intracellular stores, and interfere with GABA-A receptors. Caffeine, through antagonism of ARs, affects brain functions such as sleep, cognition, learning, and memory, and modifies brain dysfunctions and diseases: Alzheimer's disease, Parkinson's disease, Huntington's disease, Epilepsy, Pain/Migraine, Depression, Schizophrenia. In conclusion, targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ribeiro JA
Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal. jaribeiro@fm.ul.pt
Sebastião AM
No affiliation info available

MeSH

AdenosineAnimalsCaffeineCognitionHumansLearningMental DisordersModels, BiologicalNervous System DiseasesPhosphodiesterase InhibitorsPurinergic P1 Receptor AntagonistsReceptors, Purinergic P1

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20164566

Clinical Trial Links

The Impact of Caffeine on Cognition in Schizophrenia

Citation

Ribeiro, Joaquim A., and Ana M. Sebastião. "Caffeine and Adenosine." Journal of Alzheimer's Disease : JAD, vol. 20 Suppl 1, 2010, pp. S3-15.
Ribeiro JA, Sebastião AM. Caffeine and adenosine. J Alzheimers Dis. 2010;20 Suppl 1:S3-15.
Ribeiro, J. A., & Sebastião, A. M. (2010). Caffeine and adenosine. Journal of Alzheimer's Disease : JAD, 20 Suppl 1, S3-15. https://doi.org/10.3233/JAD-2010-1379
Ribeiro JA, Sebastião AM. Caffeine and Adenosine. J Alzheimers Dis. 2010;20 Suppl 1:S3-15. PubMed PMID: 20164566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine and adenosine. AU - Ribeiro,Joaquim A, AU - Sebastião,Ana M, PY - 2010/2/19/entrez PY - 2010/2/19/pubmed PY - 2010/9/3/medline SP - S3 EP - 15 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 20 Suppl 1 N2 - Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of endogenous adenosinergic tonus. Besides AR antagonism, xanthines, including caffeine, have other biological actions: they inhibit phosphodiesterases (PDEs) (e.g., PDE1, PDE4, PDE5), promote calcium release from intracellular stores, and interfere with GABA-A receptors. Caffeine, through antagonism of ARs, affects brain functions such as sleep, cognition, learning, and memory, and modifies brain dysfunctions and diseases: Alzheimer's disease, Parkinson's disease, Huntington's disease, Epilepsy, Pain/Migraine, Depression, Schizophrenia. In conclusion, targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20164566/Caffeine_and_adenosine_ L2 - https://ClinicalTrials.gov/search/term=20164566 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -