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Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases.
J Alzheimers Dis. 2010; 20 Suppl 1:S127-41.JA

Abstract

Sporadic Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common neurodegenerative diseases and as such they represent major public health problems. Finding effective treatments for AD and PD represents an unmet and elusive goal largely because these diseases are chronic and progressive, and have a complicated and ill-understood pathogenesis. Although the underlying mechanisms are not fully understood, caffeine, the most commonly ingested psychoactive drug in the world, has been shown in human and animal studies to be protective against AD and PD. One mechanism implicated in the pathogenesis of AD and PD is blood-brain barrier (BBB) dysfunction and we reported recently that caffeine exerts protective effects against AD and PD at least in part by keeping the BBB intact. The present review focuses on the role of BBB dysfunction in the pathogenesis of AD and PD, caffeine's protective effects against AD and PD, and potential mechanisms whereby caffeine protects against BBB leakage.

Authors+Show Affiliations

Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

20164568

Citation

Chen, Xuesong, et al. "Caffeine Protects Against Disruptions of the Blood-brain Barrier in Animal Models of Alzheimer's and Parkinson's Diseases." Journal of Alzheimer's Disease : JAD, vol. 20 Suppl 1, 2010, pp. S127-41.
Chen X, Ghribi O, Geiger JD. Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J Alzheimers Dis. 2010;20 Suppl 1:S127-41.
Chen, X., Ghribi, O., & Geiger, J. D. (2010). Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. Journal of Alzheimer's Disease : JAD, 20 Suppl 1, S127-41. https://doi.org/10.3233/JAD-2010-1376
Chen X, Ghribi O, Geiger JD. Caffeine Protects Against Disruptions of the Blood-brain Barrier in Animal Models of Alzheimer's and Parkinson's Diseases. J Alzheimers Dis. 2010;20 Suppl 1:S127-41. PubMed PMID: 20164568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. AU - Chen,Xuesong, AU - Ghribi,Othman, AU - Geiger,Jonathan D, PY - 2010/2/19/entrez PY - 2010/2/19/pubmed PY - 2010/9/3/medline SP - S127 EP - 41 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 20 Suppl 1 N2 - Sporadic Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common neurodegenerative diseases and as such they represent major public health problems. Finding effective treatments for AD and PD represents an unmet and elusive goal largely because these diseases are chronic and progressive, and have a complicated and ill-understood pathogenesis. Although the underlying mechanisms are not fully understood, caffeine, the most commonly ingested psychoactive drug in the world, has been shown in human and animal studies to be protective against AD and PD. One mechanism implicated in the pathogenesis of AD and PD is blood-brain barrier (BBB) dysfunction and we reported recently that caffeine exerts protective effects against AD and PD at least in part by keeping the BBB intact. The present review focuses on the role of BBB dysfunction in the pathogenesis of AD and PD, caffeine's protective effects against AD and PD, and potential mechanisms whereby caffeine protects against BBB leakage. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20164568/Caffeine_protects_against_disruptions_of_the_blood_brain_barrier_in_animal_models_of_Alzheimer's_and_Parkinson's_diseases_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20164568/ DB - PRIME DP - Unbound Medicine ER -