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Recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization.
Cornea 2010; 29(4):465-7C

Abstract

PURPOSE

To report a case of recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization.

METHODS

A 69-year-old man who had lipid keratopathy with corneal neovascularization secondary to herpes simplex keratitis in the right eye and who was treated with topical steroid received photodynamic therapy with verteporfin. Six neovascular areas in the cornea were treated consecutively to occlude new vessels and reduce the risk of allograft rejection after subsequent keratoplasty.

RESULTS

Three days after verteporfin photodynamic therapy, there was evidence of vascular occlusion. However, a herpetic epithelial ulcer was detected in the cornea. Ten days after treatment, the lesion progressed to a geographic ulcer. After topical and systemic acyclovir treatment, the lesion healed. Five months after treatment, penetrating keratoplasty and postoperative antiviral prophylaxis were performed. During a follow-up period of 12 months, the graft remained clear with visual acuity of 20/40.

CONCLUSION

Herpes simplex keratitis can recur after verteporfin photodynamic therapy for corneal neovascularization.

Authors+Show Affiliations

Department of Ophthalmology and the Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National University, Chonnam National University Medical School and Hospital, 8 Hak-dong, Gwangju, Korea. kcyoon@jnu.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20164757

Citation

Yoon, Kyung-Chul, et al. "Recurrent Herpes Simplex Keratitis After Verteporfin Photodynamic Therapy for Corneal Neovascularization." Cornea, vol. 29, no. 4, 2010, pp. 465-7.
Yoon KC, Im SK, Park HY. Recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization. Cornea. 2010;29(4):465-7.
Yoon, K. C., Im, S. K., & Park, H. Y. (2010). Recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization. Cornea, 29(4), pp. 465-7. doi:10.1097/ICO.0b013e3181b53310.
Yoon KC, Im SK, Park HY. Recurrent Herpes Simplex Keratitis After Verteporfin Photodynamic Therapy for Corneal Neovascularization. Cornea. 2010;29(4):465-7. PubMed PMID: 20164757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization. AU - Yoon,Kyung-Chul, AU - Im,Seong-Kyu, AU - Park,Hong-Yong, PY - 2010/2/19/entrez PY - 2010/2/19/pubmed PY - 2011/1/28/medline SP - 465 EP - 7 JF - Cornea JO - Cornea VL - 29 IS - 4 N2 - PURPOSE: To report a case of recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization. METHODS: A 69-year-old man who had lipid keratopathy with corneal neovascularization secondary to herpes simplex keratitis in the right eye and who was treated with topical steroid received photodynamic therapy with verteporfin. Six neovascular areas in the cornea were treated consecutively to occlude new vessels and reduce the risk of allograft rejection after subsequent keratoplasty. RESULTS: Three days after verteporfin photodynamic therapy, there was evidence of vascular occlusion. However, a herpetic epithelial ulcer was detected in the cornea. Ten days after treatment, the lesion progressed to a geographic ulcer. After topical and systemic acyclovir treatment, the lesion healed. Five months after treatment, penetrating keratoplasty and postoperative antiviral prophylaxis were performed. During a follow-up period of 12 months, the graft remained clear with visual acuity of 20/40. CONCLUSION: Herpes simplex keratitis can recur after verteporfin photodynamic therapy for corneal neovascularization. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/20164757/Recurrent_herpes_simplex_keratitis_after_verteporfin_photodynamic_therapy_for_corneal_neovascularization L2 - http://Insights.ovid.com/pubmed?pmid=20164757 DB - PRIME DP - Unbound Medicine ER -