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The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents.

Abstract

BACKGROUND

Little progress has been made to identify the central neuroendocrine pathway involved in the energy intake control in nonalcoholic fatty liver disease (NAFLD) patients.

OBJECTIVE

To assess the influence of orexigenic neuropeptides in the nutritional aspects of NAFLD obese adolescents submitted to a long-term interdisciplinary approach.

METHODS

Fifty adolescents aged 15-19 years, with body mass index at least 95th percentile, consisting of 25 patients without NAFLD and 25 with NAFLD. The NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic transaminases, and lipid profile. Insulin resistance was estimated by Homeostasis Model Assessment Insulin Resistance Index. Neuropeptide Y (NPY) and agouti related protein concentrations were measured by enzyme-linked immunosorbent assay. Analyses of food intake were made by 3 days recordatory inquiry.

RESULTS

At baseline conditions, the patients with NAFLD had significantly higher values of body mass, body mass index, visceral fat, triglycerides, VLDL-C, and hepatic transaminases. After the long-term intervention, they presented a significant reduction in these parameters. In both the groups, it was observed a significant decrease in energy intake, macronutrients and dietetic cholesterol. Only the patients with NAFLD presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY. Indeed, it was observed a positive correlation between energy intake, lipid (%) and saturated fatty acids with visceral fat accumulation.

CONCLUSION

Our findings showed an important influence of diet composition in the orexigenic system, being essential consider that the excessive saturated fatty acids intake could be a determinant factor to increase nonalcoholic fatty liver disease.

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  • Authors+Show Affiliations

    ,

    Post Graduate Program of Nutrition, Federal University of São Paulo-Unifesp, Brazil. aline.depiano@gmail.com

    , , , , , , , , , , ,

    Source

    MeSH

    Adolescent
    Agouti-Related Protein
    Eating
    Energy Metabolism
    Exercise
    Fatty Acids
    Fatty Liver
    Female
    Humans
    Intra-Abdominal Fat
    Male
    Neuropeptide Y
    Nutrition Assessment
    Obesity
    Subcutaneous Fat
    Ultrasonography
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20164781

    Citation

    de Piano, Aline, et al. "The Role of Nutritional Profile in the Orexigenic Neuropeptide Secretion in Nonalcoholic Fatty Liver Disease Obese Adolescents." European Journal of Gastroenterology & Hepatology, vol. 22, no. 5, 2010, pp. 557-63.
    de Piano A, Tock L, Carnier J, et al. The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents. Eur J Gastroenterol Hepatol. 2010;22(5):557-63.
    de Piano, A., Tock, L., Carnier, J., Foschini, D., Sanches, P. d. e. . L., Corrêa, F. A., ... Dâmaso, A. (2010). The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents. European Journal of Gastroenterology & Hepatology, 22(5), pp. 557-63. doi:10.1097/MEG.0b013e3283346df2.
    de Piano A, et al. The Role of Nutritional Profile in the Orexigenic Neuropeptide Secretion in Nonalcoholic Fatty Liver Disease Obese Adolescents. Eur J Gastroenterol Hepatol. 2010;22(5):557-63. PubMed PMID: 20164781.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents. AU - de Piano,Aline, AU - Tock,Lian, AU - Carnier,June, AU - Foschini,Denis, AU - Sanches,Priscila de Lima, AU - Corrêa,Fabíola Alvise, AU - Oyama,Lila Missae, AU - do Nascimento,Claudia Maria Oller, AU - Lederman,Henrique Manoel, AU - Ernandes,Regina, AU - de Mello,Marco Túlio, AU - Tufik,Sérgio, AU - Dâmaso,Ana, PY - 2010/2/19/entrez PY - 2010/2/19/pubmed PY - 2010/7/10/medline SP - 557 EP - 63 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 22 IS - 5 N2 - BACKGROUND: Little progress has been made to identify the central neuroendocrine pathway involved in the energy intake control in nonalcoholic fatty liver disease (NAFLD) patients. OBJECTIVE: To assess the influence of orexigenic neuropeptides in the nutritional aspects of NAFLD obese adolescents submitted to a long-term interdisciplinary approach. METHODS: Fifty adolescents aged 15-19 years, with body mass index at least 95th percentile, consisting of 25 patients without NAFLD and 25 with NAFLD. The NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic transaminases, and lipid profile. Insulin resistance was estimated by Homeostasis Model Assessment Insulin Resistance Index. Neuropeptide Y (NPY) and agouti related protein concentrations were measured by enzyme-linked immunosorbent assay. Analyses of food intake were made by 3 days recordatory inquiry. RESULTS: At baseline conditions, the patients with NAFLD had significantly higher values of body mass, body mass index, visceral fat, triglycerides, VLDL-C, and hepatic transaminases. After the long-term intervention, they presented a significant reduction in these parameters. In both the groups, it was observed a significant decrease in energy intake, macronutrients and dietetic cholesterol. Only the patients with NAFLD presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY. Indeed, it was observed a positive correlation between energy intake, lipid (%) and saturated fatty acids with visceral fat accumulation. CONCLUSION: Our findings showed an important influence of diet composition in the orexigenic system, being essential consider that the excessive saturated fatty acids intake could be a determinant factor to increase nonalcoholic fatty liver disease. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/20164781/The_role_of_nutritional_profile_in_the_orexigenic_neuropeptide_secretion_in_nonalcoholic_fatty_liver_disease_obese_adolescents_ L2 - http://Insights.ovid.com/pubmed?pmid=20164781 DB - PRIME DP - Unbound Medicine ER -