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Survival analysis of intrahepatic cholangiocarcinoma after resection.
Ann Surg Oncol. 2010 Jul; 17(7):1823-30.AS

Abstract

BACKGROUND

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, but the studies for the outcome after resection of ICC are rare. The aim of this study was to elucidate outcomes and prognostic factors of ICC in patients undergoing hepatic resection.

METHODS

A retrospective study was conducted with a total of 63 patients who underwent surgical resection with curative intent for ICC. We performed the survival analysis with preoperative and postoperative clinicopathologic factors according to the clinical outcome.

RESULTS

The cumulative 1-, 3-, and 5-year survival rates were 68.2, 50.5, and 31.8%, respectively. Univariate analysis revealed that patient's old age, high preoperative carbohydrate antigen 19-9 (CA19-9) level, major vessel invasion, T classification, lymph node metastasis, lymphatic invasion, perineural invasion, intrahepatic metastasis, and narrow resection margin were statistically significant. By multivariate analysis, patient's old age, high preoperative CA19-9 level, lymphatic invasion, and narrow resection margin were independent dismal prognostic factors. The preoperative CA19-9 level shows a significant correlation with some histopathologic factors including major vessel invasion, bile duct invasion, and perineural invasion.

CONCLUSIONS

Preoperative CA19-9 level was a valuable clinical factor for predicting histopathologic invasiveness as well as clinical outcome. An adequate resection margin was the only modifiable factor by a surgeon during hepatic resection for ICC.

Authors+Show Affiliations

National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20165987

Citation

Cho, Seong Yeon, et al. "Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection." Annals of Surgical Oncology, vol. 17, no. 7, 2010, pp. 1823-30.
Cho SY, Park SJ, Kim SH, et al. Survival analysis of intrahepatic cholangiocarcinoma after resection. Ann Surg Oncol. 2010;17(7):1823-30.
Cho, S. Y., Park, S. J., Kim, S. H., Han, S. S., Kim, Y. K., Lee, K. W., Lee, S. A., Hong, E. K., Lee, W. J., & Woo, S. M. (2010). Survival analysis of intrahepatic cholangiocarcinoma after resection. Annals of Surgical Oncology, 17(7), 1823-30. https://doi.org/10.1245/s10434-010-0938-y
Cho SY, et al. Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection. Ann Surg Oncol. 2010;17(7):1823-30. PubMed PMID: 20165987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survival analysis of intrahepatic cholangiocarcinoma after resection. AU - Cho,Seong Yeon, AU - Park,Sang-Jae, AU - Kim,Seong Hoon, AU - Han,Sung-Sik, AU - Kim,Young-Kyu, AU - Lee,Kwang-Woong, AU - Lee,Soon-Ae, AU - Hong,Eun Kyung, AU - Lee,Woo Jin, AU - Woo,Sang Myung, Y1 - 2010/02/18/ PY - 2009/04/29/received PY - 2010/2/19/entrez PY - 2010/2/19/pubmed PY - 2010/9/30/medline SP - 1823 EP - 30 JF - Annals of surgical oncology JO - Ann Surg Oncol VL - 17 IS - 7 N2 - BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, but the studies for the outcome after resection of ICC are rare. The aim of this study was to elucidate outcomes and prognostic factors of ICC in patients undergoing hepatic resection. METHODS: A retrospective study was conducted with a total of 63 patients who underwent surgical resection with curative intent for ICC. We performed the survival analysis with preoperative and postoperative clinicopathologic factors according to the clinical outcome. RESULTS: The cumulative 1-, 3-, and 5-year survival rates were 68.2, 50.5, and 31.8%, respectively. Univariate analysis revealed that patient's old age, high preoperative carbohydrate antigen 19-9 (CA19-9) level, major vessel invasion, T classification, lymph node metastasis, lymphatic invasion, perineural invasion, intrahepatic metastasis, and narrow resection margin were statistically significant. By multivariate analysis, patient's old age, high preoperative CA19-9 level, lymphatic invasion, and narrow resection margin were independent dismal prognostic factors. The preoperative CA19-9 level shows a significant correlation with some histopathologic factors including major vessel invasion, bile duct invasion, and perineural invasion. CONCLUSIONS: Preoperative CA19-9 level was a valuable clinical factor for predicting histopathologic invasiveness as well as clinical outcome. An adequate resection margin was the only modifiable factor by a surgeon during hepatic resection for ICC. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/20165987/Survival_analysis_of_intrahepatic_cholangiocarcinoma_after_resection_ L2 - https://dx.doi.org/10.1245/s10434-010-0938-y DB - PRIME DP - Unbound Medicine ER -