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[Neural tube defects in Austria: Assumption and calculations on the prevention potential through folic acid enrichment and supplementation].

Abstract

BACKGROUND

Countries with obligatory fortification of food (USA, Canada) document a significant decrease of neural tube defects in newborns.

METHODS

In this study the Daly or, respectively, the Wald method was employed for calculating the potential of fortification/and supplementation for prevention in Austria.

RESULTS

According to the EUROCAT study, in Austria the overall prevalence of neural tube defects (live birth, still births and induced abortions due to neural defect) is assumed to be 7.95 per 10,000 live and still births, and the prevalence of 3.9 per 10,000 live births - that is 62 or, respectively, 30 in absolute numbers per 78,000 births per year. In 2006, 26 live-born children with neural tube defects were actually reported in Austria by Statistik Austria.

CONCLUSION

Different folic acid fortification and supplementation strategies can avoid 1.2-1.4 per 10,000 (9-11 cases) of neural tube defects (live and still births). Folic acid supplements are effective to decrease the amount of neural tube defects, however, only when pregnancies are planned. Thus, evidence-based neural tube defects are more common among lower social groups. An obligatory fortification of food could therefore reach unplanned pregnancies and women facing social problems. A reason to justify this population-based intervention where people need not decide for themselves could be the reduction of social imbalances. There are, of course, advantages and disadvantages of obligatory fortification of food and, therefore, all circumstances have to be taken into consideration.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Ludwig Boltzmann Institut für Health Technology Assessment, Wien, Österreich.

    ,

    Source

    MeSH

    Austria
    Dietary Supplements
    Female
    Folic Acid
    Food, Fortified
    Health Policy
    Humans
    Male
    Neural Tube Defects
    Pregnancy
    Prevalence
    Proportional Hazards Models
    Regional Medical Programs
    Risk Assessment
    Risk Factors
    Vitamin B Complex

    Pub Type(s)

    English Abstract
    Journal Article

    Language

    ger

    PubMed ID

    20166011

    Citation

    Schiller-Frühwirth, I, et al. "[Neural Tube Defects in Austria: Assumption and Calculations On the Prevention Potential Through Folic Acid Enrichment and Supplementation]." Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany)), vol. 72, no. 12, 2010, pp. 880-5.
    Schiller-Frühwirth I, Mittermayr T, Wild C. [Neural tube defects in Austria: Assumption and calculations on the prevention potential through folic acid enrichment and supplementation]. Gesundheitswesen. 2010;72(12):880-5.
    Schiller-Frühwirth, I., Mittermayr, T., & Wild, C. (2010). [Neural tube defects in Austria: Assumption and calculations on the prevention potential through folic acid enrichment and supplementation]. Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany)), 72(12), pp. 880-5. doi:10.1055/s-0029-1246172.
    Schiller-Frühwirth I, Mittermayr T, Wild C. [Neural Tube Defects in Austria: Assumption and Calculations On the Prevention Potential Through Folic Acid Enrichment and Supplementation]. Gesundheitswesen. 2010;72(12):880-5. PubMed PMID: 20166011.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Neural tube defects in Austria: Assumption and calculations on the prevention potential through folic acid enrichment and supplementation]. AU - Schiller-Frühwirth,I, AU - Mittermayr,T, AU - Wild,C, Y1 - 2010/02/17/ PY - 2010/2/19/entrez PY - 2010/2/19/pubmed PY - 2011/4/19/medline SP - 880 EP - 5 JF - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) JO - Gesundheitswesen VL - 72 IS - 12 N2 - BACKGROUND: Countries with obligatory fortification of food (USA, Canada) document a significant decrease of neural tube defects in newborns. METHODS: In this study the Daly or, respectively, the Wald method was employed for calculating the potential of fortification/and supplementation for prevention in Austria. RESULTS: According to the EUROCAT study, in Austria the overall prevalence of neural tube defects (live birth, still births and induced abortions due to neural defect) is assumed to be 7.95 per 10,000 live and still births, and the prevalence of 3.9 per 10,000 live births - that is 62 or, respectively, 30 in absolute numbers per 78,000 births per year. In 2006, 26 live-born children with neural tube defects were actually reported in Austria by Statistik Austria. CONCLUSION: Different folic acid fortification and supplementation strategies can avoid 1.2-1.4 per 10,000 (9-11 cases) of neural tube defects (live and still births). Folic acid supplements are effective to decrease the amount of neural tube defects, however, only when pregnancies are planned. Thus, evidence-based neural tube defects are more common among lower social groups. An obligatory fortification of food could therefore reach unplanned pregnancies and women facing social problems. A reason to justify this population-based intervention where people need not decide for themselves could be the reduction of social imbalances. There are, of course, advantages and disadvantages of obligatory fortification of food and, therefore, all circumstances have to be taken into consideration. SN - 1439-4421 UR - https://www.unboundmedicine.com/medline/citation/20166011/[Neural_tube_defects_in_Austria:_Assumption_and_calculations_on_the_prevention_potential_through_folic_acid_enrichment_and_supplementation]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1246172 DB - PRIME DP - Unbound Medicine ER -