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S1P metabolism in cancer and other pathological conditions.
Biochimie 2010; 92(6):716-23B

Abstract

Nearly two decades ago, the sphingolipid metabolite sphingosine 1-phosphate was discovered to function as a lipid mediator and regulator of cell proliferation. Since that time, sphingosine 1-phosphate has been shown to mediate a diverse array of fundamental biological processes including cell proliferation, migration, invasion, angiogenesis, vascular maturation and lymphocyte trafficking. Sphingosine 1-phosphate acts primarily via signaling through five ubiquitously expressed G protein-coupled receptors. Intracellular sphingosine 1-phosphate molecules are transported extracellularly and gain access to cognate receptors for autocrine and paracrine signaling and for signaling at distant sites reached through blood and lymphatic circulation systems. Intracellular pools of sphingosine 1-phosphate available for signaling are tightly regulated primarily by three enzymes: sphinosine kinase, S1P lyase and S1P phosphatase. Alterations in sphingosine 1-phosphate as well as the enzymes involved in its synthesis and catabolism have been observed in many types of malignancy. These enzymes are being evaluated for their role in mediating cancer formation and progression, as well as their potential to serve as targets of anti-cancer therapeutics. In this review, the impact of sphingosine 1-phosphate, its cognate receptors, and the enzymes of sphingosine 1-phosphate metabolism on cell survival, apoptosis, autophagy, cellular transformation, invasion, angiogenesis and hypoxia in relation to cancer biology and treatment are discussed.

Authors+Show Affiliations

Children's Hospital Oakland Research Institute, 5700 Martin Luther King, Jr. Way, Oakland, CA 94609, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

20167244

Citation

Leong, Weng In, and Julie D. Saba. "S1P Metabolism in Cancer and Other Pathological Conditions." Biochimie, vol. 92, no. 6, 2010, pp. 716-23.
Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. Biochimie. 2010;92(6):716-23.
Leong, W. I., & Saba, J. D. (2010). S1P metabolism in cancer and other pathological conditions. Biochimie, 92(6), pp. 716-23. doi:10.1016/j.biochi.2010.02.014.
Leong WI, Saba JD. S1P Metabolism in Cancer and Other Pathological Conditions. Biochimie. 2010;92(6):716-23. PubMed PMID: 20167244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - S1P metabolism in cancer and other pathological conditions. AU - Leong,Weng In, AU - Saba,Julie D, Y1 - 2010/02/16/ PY - 2009/11/10/received PY - 2010/02/12/accepted PY - 2010/2/20/entrez PY - 2010/2/20/pubmed PY - 2010/9/3/medline SP - 716 EP - 23 JF - Biochimie JO - Biochimie VL - 92 IS - 6 N2 - Nearly two decades ago, the sphingolipid metabolite sphingosine 1-phosphate was discovered to function as a lipid mediator and regulator of cell proliferation. Since that time, sphingosine 1-phosphate has been shown to mediate a diverse array of fundamental biological processes including cell proliferation, migration, invasion, angiogenesis, vascular maturation and lymphocyte trafficking. Sphingosine 1-phosphate acts primarily via signaling through five ubiquitously expressed G protein-coupled receptors. Intracellular sphingosine 1-phosphate molecules are transported extracellularly and gain access to cognate receptors for autocrine and paracrine signaling and for signaling at distant sites reached through blood and lymphatic circulation systems. Intracellular pools of sphingosine 1-phosphate available for signaling are tightly regulated primarily by three enzymes: sphinosine kinase, S1P lyase and S1P phosphatase. Alterations in sphingosine 1-phosphate as well as the enzymes involved in its synthesis and catabolism have been observed in many types of malignancy. These enzymes are being evaluated for their role in mediating cancer formation and progression, as well as their potential to serve as targets of anti-cancer therapeutics. In this review, the impact of sphingosine 1-phosphate, its cognate receptors, and the enzymes of sphingosine 1-phosphate metabolism on cell survival, apoptosis, autophagy, cellular transformation, invasion, angiogenesis and hypoxia in relation to cancer biology and treatment are discussed. SN - 1638-6183 UR - https://www.unboundmedicine.com/medline/citation/20167244/S1P_metabolism_in_cancer_and_other_pathological_conditions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-9084(10)00058-1 DB - PRIME DP - Unbound Medicine ER -