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Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience.
Neuroscience. 2010 May 05; 167(2):238-46.N

Abstract

Although several pieces of evidence indicate that the endocannabinoid system modulates anxiety-like behaviors and stress adaptation, few studies have investigated the brain sites of these effects. The ventral hippocampus (VHC) has been related to anxiety behaviors and has a high expression of cannabinoid-1 (CB1) receptors. Moreover, endocannabinoid signaling in the hippocampus is proposed to regulate stress adaptation. In the present study we investigated the role of previous stressful experience on the effects of AM404, an anandamide uptake inhibitor, microinjected into the VHC of rats submitted to the elevated plus maze (EPM), a widely used animal model of anxiety. Stressed animals were forced restrained for two h 24 h before the test. AM404 (5-50 pmol) microinjection promoted an anxiogenic-like effect in non-stressed rats but decreased anxiety in stressed animals. AM251 (0.01 to 1000 pmol), a CB1 receptor antagonist, failed to change behavior in the EPM over a wide dose range but prevented the effects of AM404. Anxiolytic-like effects of AM404 (5 pmol) intra-VHC injection were also observed in the Vogel conflict test (VCT), another model of anxiety that involves previous exposure to stressful situations (48 h of water deprivation). These results suggest that facilitation of endocannabinoid system neurotransmission in the ventral hippocampus modulates anxiety-like behaviors and that this effect depends on previous stress experience.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of Sao Paulo, 3900 Bandeirantes Avenue, 14049-900, Ribeirão Preto, SP, Brazil. allinecampos@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20167262

Citation

Campos, A C., et al. "Facilitation of Endocannabinoid Effects in the Ventral Hippocampus Modulates Anxiety-like Behaviors Depending On Previous Stress Experience." Neuroscience, vol. 167, no. 2, 2010, pp. 238-46.
Campos AC, Ferreira FR, Guimarães FS, et al. Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience. Neuroscience. 2010;167(2):238-46.
Campos, A. C., Ferreira, F. R., Guimarães, F. S., & Lemos, J. I. (2010). Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience. Neuroscience, 167(2), 238-46. https://doi.org/10.1016/j.neuroscience.2010.01.062
Campos AC, et al. Facilitation of Endocannabinoid Effects in the Ventral Hippocampus Modulates Anxiety-like Behaviors Depending On Previous Stress Experience. Neuroscience. 2010 May 5;167(2):238-46. PubMed PMID: 20167262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience. AU - Campos,A C, AU - Ferreira,F R, AU - Guimarães,F S, AU - Lemos,J I, Y1 - 2010/02/16/ PY - 2009/09/27/received PY - 2010/01/25/revised PY - 2010/01/29/accepted PY - 2010/2/20/entrez PY - 2010/2/20/pubmed PY - 2010/6/18/medline SP - 238 EP - 46 JF - Neuroscience JO - Neuroscience VL - 167 IS - 2 N2 - Although several pieces of evidence indicate that the endocannabinoid system modulates anxiety-like behaviors and stress adaptation, few studies have investigated the brain sites of these effects. The ventral hippocampus (VHC) has been related to anxiety behaviors and has a high expression of cannabinoid-1 (CB1) receptors. Moreover, endocannabinoid signaling in the hippocampus is proposed to regulate stress adaptation. In the present study we investigated the role of previous stressful experience on the effects of AM404, an anandamide uptake inhibitor, microinjected into the VHC of rats submitted to the elevated plus maze (EPM), a widely used animal model of anxiety. Stressed animals were forced restrained for two h 24 h before the test. AM404 (5-50 pmol) microinjection promoted an anxiogenic-like effect in non-stressed rats but decreased anxiety in stressed animals. AM251 (0.01 to 1000 pmol), a CB1 receptor antagonist, failed to change behavior in the EPM over a wide dose range but prevented the effects of AM404. Anxiolytic-like effects of AM404 (5 pmol) intra-VHC injection were also observed in the Vogel conflict test (VCT), another model of anxiety that involves previous exposure to stressful situations (48 h of water deprivation). These results suggest that facilitation of endocannabinoid system neurotransmission in the ventral hippocampus modulates anxiety-like behaviors and that this effect depends on previous stress experience. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/20167262/Facilitation_of_endocannabinoid_effects_in_the_ventral_hippocampus_modulates_anxiety_like_behaviors_depending_on_previous_stress_experience_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(10)00154-5 DB - PRIME DP - Unbound Medicine ER -