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Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells.
J Asthma. 2010 Mar; 47(2):117-23.JA

Abstract

Asthma is an epithelial disorder in which T helper 2 (Th2)-type inflammation has a prominent role. Recent studies indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma. The authors used ovalbumin (OVA) sensitization and challenge to induce a murine asthmatic model. The model was confirmed by airway hyperresponsiveness, serum levels of total and OVA-specific immunoglobulin (IgE), histological analysis of lung tissues. The authors found that expression of TSLP was significantly increased in both mRNA and protein levels in mice lungs treated with OVA. The expression of CD40, CD80, and CD86 in bronchoalveolar lavage fluid (BALF) was increased in mice with OVA. Tight correlation between TSLP mRNA and interleukin (IL)-4, IL-5, and IL-13 in BALF was identified. Furthermore, treating mice with TSLP-neutralizing antibody reduced the expression of TSLP mRNA of lungs, CD40, CD80, and CD86 on dendritic cells, and IL-4, IL-5, and IL-13 in the OVA group. This study indicates that TSLP is increased in the airway epithelium in mice treated with OVA. In the lung inflammation model, TSLP activates dendritic cells (DCs) via up-regulation of CD40, CD80, and CD86, then induces the differentiation of prime naive CD4(+) T cells to become proinflammatory Th2 cells. Blocking TSLP is capable of inhibiting the production of Th2 cytokines, thus presents a promising strategy for the treatment of asthma.

Authors+Show Affiliations

1Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20170316

Citation

Li, Yan-Li, et al. "Thymic Stromal Lymphopoietin Promotes Lung Inflammation Through Activation of Dendritic Cells." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 47, no. 2, 2010, pp. 117-23.
Li YL, Li HJ, Ji F, et al. Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells. J Asthma. 2010;47(2):117-23.
Li, Y. L., Li, H. J., Ji, F., Zhang, X., Wang, R., Hao, J. Q., Bi, W. X., & Dong, L. (2010). Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 47(2), 117-23. https://doi.org/10.3109/02770900903483816
Li YL, et al. Thymic Stromal Lymphopoietin Promotes Lung Inflammation Through Activation of Dendritic Cells. J Asthma. 2010;47(2):117-23. PubMed PMID: 20170316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells. AU - Li,Yan-Li, AU - Li,Hong-Jia, AU - Ji,Feng, AU - Zhang,Xiao, AU - Wang,Rong, AU - Hao,Jun-Qing, AU - Bi,Wen-Xiang, AU - Dong,Liang, PY - 2010/2/23/entrez PY - 2010/2/23/pubmed PY - 2010/4/7/medline SP - 117 EP - 23 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 47 IS - 2 N2 - Asthma is an epithelial disorder in which T helper 2 (Th2)-type inflammation has a prominent role. Recent studies indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma. The authors used ovalbumin (OVA) sensitization and challenge to induce a murine asthmatic model. The model was confirmed by airway hyperresponsiveness, serum levels of total and OVA-specific immunoglobulin (IgE), histological analysis of lung tissues. The authors found that expression of TSLP was significantly increased in both mRNA and protein levels in mice lungs treated with OVA. The expression of CD40, CD80, and CD86 in bronchoalveolar lavage fluid (BALF) was increased in mice with OVA. Tight correlation between TSLP mRNA and interleukin (IL)-4, IL-5, and IL-13 in BALF was identified. Furthermore, treating mice with TSLP-neutralizing antibody reduced the expression of TSLP mRNA of lungs, CD40, CD80, and CD86 on dendritic cells, and IL-4, IL-5, and IL-13 in the OVA group. This study indicates that TSLP is increased in the airway epithelium in mice treated with OVA. In the lung inflammation model, TSLP activates dendritic cells (DCs) via up-regulation of CD40, CD80, and CD86, then induces the differentiation of prime naive CD4(+) T cells to become proinflammatory Th2 cells. Blocking TSLP is capable of inhibiting the production of Th2 cytokines, thus presents a promising strategy for the treatment of asthma. SN - 1532-4303 UR - https://www.unboundmedicine.com/medline/citation/20170316/Thymic_stromal_lymphopoietin_promotes_lung_inflammation_through_activation_of_dendritic_cells_ L2 - https://www.tandfonline.com/doi/full/10.3109/02770900903483816 DB - PRIME DP - Unbound Medicine ER -