Tags

Type your tag names separated by a space and hit enter

Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease.
Biochim Biophys Acta 2010; 1801(8):906-16BB

Abstract

Degradation of glycerophospholipids, sphingolipids and cholesterol in the nucleus modulates neural cell proliferation and differentiation, inflammation, apoptosis, migration, cell adhesion, and intracellular trafficking. Extracellular signals from agonists (neurotransmitters, cytokines, and growth factors) regulate the activity of a key set of lipid-metabolizing enzymes, such as phospholipases, sphingomyelinases, and cholesterol hydroxylases. These enzymes and their downstream targets constitute a complex lipid signaling network with multiple nodes of interaction and cross-regulation through their lipid mediators, which include eicosanoids, docosanoids, diacylglycerols, platelet activating factor, lysophosphatidic acid, ceramide and ceramide 1-phosphate, sphingosine and sphingosine 1-phosphate, and hydroxycholesterols. Receptors for above lipid mediators are localized at the neural cell nucleus. Stimulation of isolated nuclei with these lipids and agonists results in changes in transcriptional regulation of major genes, including c-fos, cylooxygenase-2, secretory phospholipase A(2) and endothelial as well as inducible nitric oxide synthases. Imbalances in signaling network involving above genes may contribute to the pathogenesis of human neurological disorders. In this review, we have attempted to integrate available information on above lipid mediators in the nucleus. In addition, attempts have been made to explain cross-talk among glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in neural cell death in Alzheimer's disease.

Authors+Show Affiliations

Department of Molecular Cellular Biochemistry, The Ohio State University, Columbus, OH 43221, USA. farooqui.1@osu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20170745

Citation

Farooqui, Akhlaq A., et al. "Lipid Mediators in the Nucleus: Their Potential Contribution to Alzheimer's Disease." Biochimica Et Biophysica Acta, vol. 1801, no. 8, 2010, pp. 906-16.
Farooqui AA, Ong WY, Farooqui T. Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease. Biochim Biophys Acta. 2010;1801(8):906-16.
Farooqui, A. A., Ong, W. Y., & Farooqui, T. (2010). Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease. Biochimica Et Biophysica Acta, 1801(8), pp. 906-16. doi:10.1016/j.bbalip.2010.02.002.
Farooqui AA, Ong WY, Farooqui T. Lipid Mediators in the Nucleus: Their Potential Contribution to Alzheimer's Disease. Biochim Biophys Acta. 2010;1801(8):906-16. PubMed PMID: 20170745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease. AU - Farooqui,Akhlaq A, AU - Ong,Wei-Yi, AU - Farooqui,Tahira, Y1 - 2010/02/17/ PY - 2009/12/10/received PY - 2010/01/29/revised PY - 2010/02/01/accepted PY - 2010/2/23/entrez PY - 2010/2/23/pubmed PY - 2010/8/11/medline SP - 906 EP - 16 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1801 IS - 8 N2 - Degradation of glycerophospholipids, sphingolipids and cholesterol in the nucleus modulates neural cell proliferation and differentiation, inflammation, apoptosis, migration, cell adhesion, and intracellular trafficking. Extracellular signals from agonists (neurotransmitters, cytokines, and growth factors) regulate the activity of a key set of lipid-metabolizing enzymes, such as phospholipases, sphingomyelinases, and cholesterol hydroxylases. These enzymes and their downstream targets constitute a complex lipid signaling network with multiple nodes of interaction and cross-regulation through their lipid mediators, which include eicosanoids, docosanoids, diacylglycerols, platelet activating factor, lysophosphatidic acid, ceramide and ceramide 1-phosphate, sphingosine and sphingosine 1-phosphate, and hydroxycholesterols. Receptors for above lipid mediators are localized at the neural cell nucleus. Stimulation of isolated nuclei with these lipids and agonists results in changes in transcriptional regulation of major genes, including c-fos, cylooxygenase-2, secretory phospholipase A(2) and endothelial as well as inducible nitric oxide synthases. Imbalances in signaling network involving above genes may contribute to the pathogenesis of human neurological disorders. In this review, we have attempted to integrate available information on above lipid mediators in the nucleus. In addition, attempts have been made to explain cross-talk among glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in neural cell death in Alzheimer's disease. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/20170745/Lipid_mediators_in_the_nucleus:_Their_potential_contribution_to_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-1981(10)00028-4 DB - PRIME DP - Unbound Medicine ER -