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Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in rats.
Peptides. 2010 May; 31(5):889-92.P

Abstract

The renin-angiotensin system (RAS) is an essential regulator of the blood pressure and body fluid balance, but the processing cascade or role of the tissue RAS remains obscure. Proangiotensin-12 (proang-12), a novel angiotensin peptide recently discovered in rat tissues, is assumed to function as a factor of the tissue RAS. To investigate the tissue production of proang-12, we measured the circulating and tissue components of the RAS including proang-12 following low-, normal-, or high-salt feeding in rats. Twelve-week-old male Wistar rats were fed a low-salt 0.3% NaCl or high-salt 8% NaCl diet for 7 days and compared with those fed a normal-salt diet of 0.7% NaCl. Low-salt feeding elevated the plasma renin activity and aldosterone concentration, resulting in significant increases in Ang I and Ang II levels in the plasma or kidney tissue, as compared with the normal- or high-salt group. Despite the increases in plasma renin activity, Ang I, and Ang II, the proang-12 levels in plasma and various tissues including the kidneys, small intestine, cardiac ventricles, and brain remained unchanged following low-salt feeding. These results suggest that peptide levels of proang-12 in rat plasma and tissues are regulated in a manner independent of the circulating RAS.

Authors+Show Affiliations

Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. saya223@fc.miyazaki-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20172005

Citation

Nagata, Sayaka, et al. "Plasma and Tissue Levels of Proangiotensin-12 and Components of the Renin-angiotensin System (RAS) Following Low- or High-salt Feeding in Rats." Peptides, vol. 31, no. 5, 2010, pp. 889-92.
Nagata S, Kato J, Kuwasako K, et al. Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in rats. Peptides. 2010;31(5):889-92.
Nagata, S., Kato, J., Kuwasako, K., & Kitamura, K. (2010). Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in rats. Peptides, 31(5), 889-92. https://doi.org/10.1016/j.peptides.2010.02.008
Nagata S, et al. Plasma and Tissue Levels of Proangiotensin-12 and Components of the Renin-angiotensin System (RAS) Following Low- or High-salt Feeding in Rats. Peptides. 2010;31(5):889-92. PubMed PMID: 20172005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in rats. AU - Nagata,Sayaka, AU - Kato,Johji, AU - Kuwasako,Kenji, AU - Kitamura,Kazuo, Y1 - 2010/02/19/ PY - 2009/07/16/received PY - 2010/02/10/revised PY - 2010/02/10/accepted PY - 2010/2/23/entrez PY - 2010/2/23/pubmed PY - 2010/6/30/medline SP - 889 EP - 92 JF - Peptides JO - Peptides VL - 31 IS - 5 N2 - The renin-angiotensin system (RAS) is an essential regulator of the blood pressure and body fluid balance, but the processing cascade or role of the tissue RAS remains obscure. Proangiotensin-12 (proang-12), a novel angiotensin peptide recently discovered in rat tissues, is assumed to function as a factor of the tissue RAS. To investigate the tissue production of proang-12, we measured the circulating and tissue components of the RAS including proang-12 following low-, normal-, or high-salt feeding in rats. Twelve-week-old male Wistar rats were fed a low-salt 0.3% NaCl or high-salt 8% NaCl diet for 7 days and compared with those fed a normal-salt diet of 0.7% NaCl. Low-salt feeding elevated the plasma renin activity and aldosterone concentration, resulting in significant increases in Ang I and Ang II levels in the plasma or kidney tissue, as compared with the normal- or high-salt group. Despite the increases in plasma renin activity, Ang I, and Ang II, the proang-12 levels in plasma and various tissues including the kidneys, small intestine, cardiac ventricles, and brain remained unchanged following low-salt feeding. These results suggest that peptide levels of proang-12 in rat plasma and tissues are regulated in a manner independent of the circulating RAS. SN - 1873-5169 UR - https://www.unboundmedicine.com/medline/citation/20172005/Plasma_and_tissue_levels_of_proangiotensin_12_and_components_of_the_renin_angiotensin_system__RAS__following_low__or_high_salt_feeding_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(10)00062-8 DB - PRIME DP - Unbound Medicine ER -