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Selenium induces changes in the selenocysteine tRNA[Ser]Sec population in mammalian cells.
Nucleic Acids Res. 1991 Feb 25; 19(4):939-43.NA

Abstract

Two isoacceptors of selenocysteine tRNA[Ser]Sec are present in higher vertebrates which are responsible for donating selenocysteine to protein. One such selenocysteine containing protein, glutathione peroxidase, requires selenium for its translation and transcription. Since tRNA[Ser]Sec is a critical component of the glutathione peroxidase translational machinery, the levels and distributions of its isoacceptors were examined from both human and rat cells grown in chemically defined media with and without selenium. Not only did the level of the selenocysteine tRNA[Ser]Sec population increase approximately 20% in cells grown in the presence of selenium, but the distributions of the two isoacceptors also changed relative to each other.

Authors+Show Affiliations

Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2017375

Citation

Hatfield, D, et al. "Selenium Induces Changes in the Selenocysteine tRNA[Ser]Sec Population in Mammalian Cells." Nucleic Acids Research, vol. 19, no. 4, 1991, pp. 939-43.
Hatfield D, Lee BJ, Hampton L, et al. Selenium induces changes in the selenocysteine tRNA[Ser]Sec population in mammalian cells. Nucleic Acids Res. 1991;19(4):939-43.
Hatfield, D., Lee, B. J., Hampton, L., & Diamond, A. M. (1991). Selenium induces changes in the selenocysteine tRNA[Ser]Sec population in mammalian cells. Nucleic Acids Research, 19(4), 939-43.
Hatfield D, et al. Selenium Induces Changes in the Selenocysteine tRNA[Ser]Sec Population in Mammalian Cells. Nucleic Acids Res. 1991 Feb 25;19(4):939-43. PubMed PMID: 2017375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium induces changes in the selenocysteine tRNA[Ser]Sec population in mammalian cells. AU - Hatfield,D, AU - Lee,B J, AU - Hampton,L, AU - Diamond,A M, PY - 1991/2/25/pubmed PY - 1991/2/25/medline PY - 1991/2/25/entrez SP - 939 EP - 43 JF - Nucleic acids research JO - Nucleic Acids Res. VL - 19 IS - 4 N2 - Two isoacceptors of selenocysteine tRNA[Ser]Sec are present in higher vertebrates which are responsible for donating selenocysteine to protein. One such selenocysteine containing protein, glutathione peroxidase, requires selenium for its translation and transcription. Since tRNA[Ser]Sec is a critical component of the glutathione peroxidase translational machinery, the levels and distributions of its isoacceptors were examined from both human and rat cells grown in chemically defined media with and without selenium. Not only did the level of the selenocysteine tRNA[Ser]Sec population increase approximately 20% in cells grown in the presence of selenium, but the distributions of the two isoacceptors also changed relative to each other. SN - 0305-1048 UR - https://www.unboundmedicine.com/medline/citation/2017375/Selenium_induces_changes_in_the_selenocysteine_tRNA[Ser]Sec_population_in_mammalian_cells_ L2 - https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/19.4.939 DB - PRIME DP - Unbound Medicine ER -