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The role of menin in parathyroid tumorigenesis.
Adv Exp Med Biol. 2009; 668:79-86.AE

Abstract

Primary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to be fully understood. In recent years interest has focussed on the interaction between menin protein and the transforming growth factor (TGF)-beta/Smad signalling pathway. In vitro experimentation has demonstrated that the presence of menin is required for TGF-beta to effectively inhibit parathyroid cell proliferation and PTH production. This observation correlates with the almost universal occurrence of parathyroid tumors accompanying the inactivation of menin in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of somatic menin gene mutations seen in sporadic parathyroid adenomas. This chapter aims to review the role of menin in primary hyperparathyroidism and parathyroid hormone-regulation, including the influences of MEN1 gene mutations on parathyroid cell proliferation, differentiation and tumorigenesis.

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Authors+Show Affiliations

Davenport C
Academic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland Medical School, Beaumont Road, Dublin 9, Ireland.
Agha A
No affiliation info available

MeSH

HumansHyperparathyroidism, PrimaryMultiple Endocrine Neoplasia Type 1MutationParathyroid GlandsParathyroid HormoneParathyroid NeoplasmsProto-Oncogene ProteinsSignal TransductionSmad ProteinsTransforming Growth Factor beta

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20175455

Citation

Davenport, Colin, and Amar Agha. "The Role of Menin in Parathyroid Tumorigenesis." Advances in Experimental Medicine and Biology, vol. 668, 2009, pp. 79-86.
Davenport C, Agha A. The role of menin in parathyroid tumorigenesis. Adv Exp Med Biol. 2009;668:79-86.
Davenport, C., & Agha, A. (2009). The role of menin in parathyroid tumorigenesis. Advances in Experimental Medicine and Biology, 668, 79-86.
Davenport C, Agha A. The Role of Menin in Parathyroid Tumorigenesis. Adv Exp Med Biol. 2009;668:79-86. PubMed PMID: 20175455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of menin in parathyroid tumorigenesis. AU - Davenport,Colin, AU - Agha,Amar, PY - 2010/2/24/entrez PY - 2010/2/24/pubmed PY - 2010/4/7/medline SP - 79 EP - 86 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 668 N2 - Primary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to be fully understood. In recent years interest has focussed on the interaction between menin protein and the transforming growth factor (TGF)-beta/Smad signalling pathway. In vitro experimentation has demonstrated that the presence of menin is required for TGF-beta to effectively inhibit parathyroid cell proliferation and PTH production. This observation correlates with the almost universal occurrence of parathyroid tumors accompanying the inactivation of menin in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of somatic menin gene mutations seen in sporadic parathyroid adenomas. This chapter aims to review the role of menin in primary hyperparathyroidism and parathyroid hormone-regulation, including the influences of MEN1 gene mutations on parathyroid cell proliferation, differentiation and tumorigenesis. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/20175455/The_role_of_menin_in_parathyroid_tumorigenesis_ L2 - https://dx.doi.org/10.1007/978-1-4419-1664-8_8 DB - PRIME DP - Unbound Medicine ER -