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Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis.
Aliment Pharmacol Ther. 2010 May; 31(9):1042-50.AP

Abstract

BACKGROUND

Atrophic gastritis, involving the gastric body mucosa, predisposes to gastric neoplastic lesions (GNL). However, regular gastroscopic-histological follow-up for GNL is not recommended for patients with atrophic gastritis.

AIM

To evaluate risk factors for the progression to GNL in a cohort of patients with atrophic gastritis.

METHODS

A total of 300 patients with atrophic gastritis [205 women, aged 54 (18-78) years] underwent gastroscopy with six gastric antrum and body biopsies. All patients had at least one follow-up gastroscopy/histology at an interval of at least 1 year after the atrophic gastritis diagnosis. Baseline clinical and histological features were analysed as risk factors for the development of GNL by Cox-regression.

RESULTS

During a median follow-up of 4.3 (1-16.5) years, 15 GNL were detected in 14 of the 300 patients with atrophic gastritis: three were gastric cancer, whereas 12 were non-invasive neoplasia. The annual incidence for GNL was 1%. Cox-regression analysis identified the following risk factors: age over 50 years (HR 8.8, 95%CI 1.2-68.4), atrophic pangastritis (HR 4.5, 95% CI 1.5-14.1) and severe intestinal metaplasia in the gastric body (HR 4.0, 95% CI 1.3-11.8).

CONCLUSIONS

Atrophic pangastritis, severe body intestinal metaplasia and/or age over 50 years increase the risk for developing GNL in patients with atrophic gastritis. In this subset of patients, an endoscopic-histological follow-up for GNL surveillance may be worthwhile.

Authors+Show Affiliations

Department of Digestive and Liver Disease, Sant'Andrea Hospital, II School of Medicine, University Sapienza of Rome, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20175768

Citation

Vannella, L, et al. "Risk Factors for Progression to Gastric Neoplastic Lesions in Patients With Atrophic Gastritis." Alimentary Pharmacology & Therapeutics, vol. 31, no. 9, 2010, pp. 1042-50.
Vannella L, Lahner E, Osborn J, et al. Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis. Aliment Pharmacol Ther. 2010;31(9):1042-50.
Vannella, L., Lahner, E., Osborn, J., Bordi, C., Miglione, M., Delle Fave, G., & Annibale, B. (2010). Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis. Alimentary Pharmacology & Therapeutics, 31(9), 1042-50. https://doi.org/10.1111/j.1365-2036.2010.04268.x
Vannella L, et al. Risk Factors for Progression to Gastric Neoplastic Lesions in Patients With Atrophic Gastritis. Aliment Pharmacol Ther. 2010;31(9):1042-50. PubMed PMID: 20175768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis. AU - Vannella,L, AU - Lahner,E, AU - Osborn,J, AU - Bordi,C, AU - Miglione,M, AU - Delle Fave,G, AU - Annibale,B, Y1 - 2010/02/18/ PY - 2010/2/24/entrez PY - 2010/2/24/pubmed PY - 2010/11/6/medline SP - 1042 EP - 50 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 31 IS - 9 N2 - BACKGROUND: Atrophic gastritis, involving the gastric body mucosa, predisposes to gastric neoplastic lesions (GNL). However, regular gastroscopic-histological follow-up for GNL is not recommended for patients with atrophic gastritis. AIM: To evaluate risk factors for the progression to GNL in a cohort of patients with atrophic gastritis. METHODS: A total of 300 patients with atrophic gastritis [205 women, aged 54 (18-78) years] underwent gastroscopy with six gastric antrum and body biopsies. All patients had at least one follow-up gastroscopy/histology at an interval of at least 1 year after the atrophic gastritis diagnosis. Baseline clinical and histological features were analysed as risk factors for the development of GNL by Cox-regression. RESULTS: During a median follow-up of 4.3 (1-16.5) years, 15 GNL were detected in 14 of the 300 patients with atrophic gastritis: three were gastric cancer, whereas 12 were non-invasive neoplasia. The annual incidence for GNL was 1%. Cox-regression analysis identified the following risk factors: age over 50 years (HR 8.8, 95%CI 1.2-68.4), atrophic pangastritis (HR 4.5, 95% CI 1.5-14.1) and severe intestinal metaplasia in the gastric body (HR 4.0, 95% CI 1.3-11.8). CONCLUSIONS: Atrophic pangastritis, severe body intestinal metaplasia and/or age over 50 years increase the risk for developing GNL in patients with atrophic gastritis. In this subset of patients, an endoscopic-histological follow-up for GNL surveillance may be worthwhile. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/20175768/Risk_factors_for_progression_to_gastric_neoplastic_lesions_in_patients_with_atrophic_gastritis_ L2 - https://doi.org/10.1111/j.1365-2036.2010.04268.x DB - PRIME DP - Unbound Medicine ER -