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Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases.
J Cutan Pathol 2010; 37(9):1002-9JC

Abstract

Microcystic adnexal carcinoma (MAC) is a rare, usually solitary, slowly growing, yet aggressive neoplasm with a tendency for local recurrences. Herein, we present two patients who had been histopathologically diagnosed as suffering from MAC on both cheeks since childhood, an unlikely scenario. Both from a clinical and from a histopathological point of view, our two cases showed some similarities with those previously described in patients with Nicolau-Balus syndrome, Rombo syndrome, and so-called eccrine-pilar hamartoma. Common to all these latter disorders are the round aggregations of elastic tissue in the papillary dermis, a histopathological feature which was also found in our patients. However, to our knowledge, the presence of a MAC-like ductal proliferation embedded in sclerotic stroma and extending to the deep dermis has not been previously described. Dermatologists and dermatopathologists should be aware of this disorder to avoid overdiagnosis of and inappropriate treatment for MAC.

Authors+Show Affiliations

Department of Dermatohistology, St. Barbara Hospital, Catholic Clinics Duisburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20175822

Citation

Schaller, Jörg, et al. "Sweat Duct Proliferation Associated With Aggregates of Elastic Tissue and Atrophodermia Vermiculata: a Simulator of Microcystic Adnexal Carcinoma. Report of Two Cases." Journal of Cutaneous Pathology, vol. 37, no. 9, 2010, pp. 1002-9.
Schaller J, Rytina E, Rütten A, et al. Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases. J Cutan Pathol. 2010;37(9):1002-9.
Schaller, J., Rytina, E., Rütten, A., Hendricks, C., Ha, T., & Requena, L. (2010). Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases. Journal of Cutaneous Pathology, 37(9), pp. 1002-9. doi:10.1111/j.1600-0560.2010.01527.x.
Schaller J, et al. Sweat Duct Proliferation Associated With Aggregates of Elastic Tissue and Atrophodermia Vermiculata: a Simulator of Microcystic Adnexal Carcinoma. Report of Two Cases. J Cutan Pathol. 2010;37(9):1002-9. PubMed PMID: 20175822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases. AU - Schaller,Jörg, AU - Rytina,Ed, AU - Rütten,Arno, AU - Hendricks,Carlo, AU - Ha,Tom, AU - Requena,Luis, Y1 - 2010/02/18/ PY - 2010/2/24/entrez PY - 2010/2/24/pubmed PY - 2010/10/27/medline SP - 1002 EP - 9 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 37 IS - 9 N2 - Microcystic adnexal carcinoma (MAC) is a rare, usually solitary, slowly growing, yet aggressive neoplasm with a tendency for local recurrences. Herein, we present two patients who had been histopathologically diagnosed as suffering from MAC on both cheeks since childhood, an unlikely scenario. Both from a clinical and from a histopathological point of view, our two cases showed some similarities with those previously described in patients with Nicolau-Balus syndrome, Rombo syndrome, and so-called eccrine-pilar hamartoma. Common to all these latter disorders are the round aggregations of elastic tissue in the papillary dermis, a histopathological feature which was also found in our patients. However, to our knowledge, the presence of a MAC-like ductal proliferation embedded in sclerotic stroma and extending to the deep dermis has not been previously described. Dermatologists and dermatopathologists should be aware of this disorder to avoid overdiagnosis of and inappropriate treatment for MAC. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/20175822/Sweat_duct_proliferation_associated_with_aggregates_of_elastic_tissue_and_atrophodermia_vermiculata:_a_simulator_of_microcystic_adnexal_carcinoma__Report_of_two_cases_ L2 - https://doi.org/10.1111/j.1600-0560.2010.01527.x DB - PRIME DP - Unbound Medicine ER -