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Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain.
Behav Brain Res. 2010 Jul 11; 210(2):171-7.BB

Abstract

The root part of Paeonia lactiflora Pall., commonly known as peony, is a commonly used Chinese herb for the treatment of depression-like disorders. Previous studies in our laboratory have showed that total glycosides of peony (TGP) produced antidepressant-like action in various mouse models of behavioral despair. The present study aimed to investigate the mechanism(s) underlying the antidepressant-like action of TGP by measuring neurotrophins including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in non-stressed and chronic unpredictable mild stress (CUMS)-treated rats. TGP (80 or 160 mg/kg/day) was administered by oral gavage to the animals for 5 weeks. The results showed that CUMS caused depression-like behavior in rats, as indicated by the significant decreases in sucrose consumption and locomotor activity (assessed by open-field test). In addition, it was found that BDNF contents in the hippocampus and frontal cortex were significantly decreased in CUMS-treated rats. CUMS treatment also significantly decreased the level of NGF in the frontal cortex of the animals. Daily intragastric administration of TGP (80 or 160 mg/kg/day) during the five weeks of CUMS significantly suppressed behavioral and biochemical changes induced by CUMS. Treating non-stressed animals with TGP (160 mg/kg) for 5 weeks also significantly increased BDNF contents in the hippocampus and frontal cortex, and NGF contents in the frontal cortex. The results suggest that the antidepressant-like action of TGP is mediated, at least in part, by increasing the expression of BDNF and NGF in selective brain tissues.

Authors+Show Affiliations

School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20176057

Citation

Mao, Qing-Qiu, et al. "Long-term Treatment With Peony Glycosides Reverses Chronic Unpredictable Mild Stress-induced Depressive-like Behavior Via Increasing Expression of Neurotrophins in Rat Brain." Behavioural Brain Research, vol. 210, no. 2, 2010, pp. 171-7.
Mao QQ, Xian YF, Ip SP, et al. Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. Behav Brain Res. 2010;210(2):171-7.
Mao, Q. Q., Xian, Y. F., Ip, S. P., Tsai, S. H., & Che, C. T. (2010). Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. Behavioural Brain Research, 210(2), 171-7. https://doi.org/10.1016/j.bbr.2010.02.026
Mao QQ, et al. Long-term Treatment With Peony Glycosides Reverses Chronic Unpredictable Mild Stress-induced Depressive-like Behavior Via Increasing Expression of Neurotrophins in Rat Brain. Behav Brain Res. 2010 Jul 11;210(2):171-7. PubMed PMID: 20176057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. AU - Mao,Qing-Qiu, AU - Xian,Yan-Fang, AU - Ip,Siu-Po, AU - Tsai,Sam-Hip, AU - Che,Chun-Tao, Y1 - 2010/02/20/ PY - 2009/08/13/received PY - 2010/02/10/revised PY - 2010/02/12/accepted PY - 2010/2/24/entrez PY - 2010/2/24/pubmed PY - 2010/8/11/medline SP - 171 EP - 7 JF - Behavioural brain research JO - Behav. Brain Res. VL - 210 IS - 2 N2 - The root part of Paeonia lactiflora Pall., commonly known as peony, is a commonly used Chinese herb for the treatment of depression-like disorders. Previous studies in our laboratory have showed that total glycosides of peony (TGP) produced antidepressant-like action in various mouse models of behavioral despair. The present study aimed to investigate the mechanism(s) underlying the antidepressant-like action of TGP by measuring neurotrophins including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in non-stressed and chronic unpredictable mild stress (CUMS)-treated rats. TGP (80 or 160 mg/kg/day) was administered by oral gavage to the animals for 5 weeks. The results showed that CUMS caused depression-like behavior in rats, as indicated by the significant decreases in sucrose consumption and locomotor activity (assessed by open-field test). In addition, it was found that BDNF contents in the hippocampus and frontal cortex were significantly decreased in CUMS-treated rats. CUMS treatment also significantly decreased the level of NGF in the frontal cortex of the animals. Daily intragastric administration of TGP (80 or 160 mg/kg/day) during the five weeks of CUMS significantly suppressed behavioral and biochemical changes induced by CUMS. Treating non-stressed animals with TGP (160 mg/kg) for 5 weeks also significantly increased BDNF contents in the hippocampus and frontal cortex, and NGF contents in the frontal cortex. The results suggest that the antidepressant-like action of TGP is mediated, at least in part, by increasing the expression of BDNF and NGF in selective brain tissues. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20176057/Long_term_treatment_with_peony_glycosides_reverses_chronic_unpredictable_mild_stress_induced_depressive_like_behavior_via_increasing_expression_of_neurotrophins_in_rat_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00126-9 DB - PRIME DP - Unbound Medicine ER -