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Stress-induced changes in mood and cortisol release predict mood effects of amphetamine.
Drug Alcohol Depend. 2010 Jun 01; 109(1-3):175-80.DA

Abstract

BACKGROUND

Stress is thought to contribute to both initiation and relapse to drug abuse. However, the mechanisms by which stress influences drug use are unclear. Interestingly, responses to acute administration of stimulant drugs resemble certain neuronal and hormonal responses to acute stress, and there is accumulating evidence that individual variation in the positive reinforcing or euphorigenic effects of a drug is related to individual differences in responsivity to acute stress.

METHODS

In this study we evaluated relationships between physiological and subjective responses to a stressful task and to an oral dose of d-amphetamine in healthy adult volunteers (N=34). Individuals participated in four experimental sessions; two behavioral sessions involving a stressful task (i.e., public speech) or a non-stressful control task, and two drug sessions involving oral administration of d-amphetamine (20mg) or a placebo. The dependent measures included salivary cortisol, heart rate, mean arterial pressure, and subjective ratings of mood.

RESULTS

As expected, both stress and d-amphetamine increased cortisol, heart rate and blood pressure. Stress increased negative mood, whereas d-amphetamine induced prototypic stimulant effects and increased ratings of drug liking. Analyses revealed that increased negative mood states after stress were correlated with positive mood after amphetamine. In addition, increased cortisol after stress was correlated with positive mood responses to amphetamine. Finally, there were modest positive correlations between cortisol and heart rate increases after stress and mean arterial pressure after amphetamine.

CONCLUSIONS

These results support and extend previous observations that responses to acute stress are correlated with certain subjective, hormonal and cardiovascular effects of a stimulant drug.

Authors+Show Affiliations

The University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Avenue MC-3077, Chicago, IL 60637, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20176450

Citation

Hamidovic, Ajna, et al. "Stress-induced Changes in Mood and Cortisol Release Predict Mood Effects of Amphetamine." Drug and Alcohol Dependence, vol. 109, no. 1-3, 2010, pp. 175-80.
Hamidovic A, Childs E, Conrad M, et al. Stress-induced changes in mood and cortisol release predict mood effects of amphetamine. Drug Alcohol Depend. 2010;109(1-3):175-80.
Hamidovic, A., Childs, E., Conrad, M., King, A., & de Wit, H. (2010). Stress-induced changes in mood and cortisol release predict mood effects of amphetamine. Drug and Alcohol Dependence, 109(1-3), 175-80. https://doi.org/10.1016/j.drugalcdep.2009.12.029
Hamidovic A, et al. Stress-induced Changes in Mood and Cortisol Release Predict Mood Effects of Amphetamine. Drug Alcohol Depend. 2010 Jun 1;109(1-3):175-80. PubMed PMID: 20176450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress-induced changes in mood and cortisol release predict mood effects of amphetamine. AU - Hamidovic,Ajna, AU - Childs,Emma, AU - Conrad,Megan, AU - King,Andrea, AU - de Wit,Harriet, Y1 - 2010/02/21/ PY - 2009/08/17/received PY - 2009/12/21/revised PY - 2009/12/28/accepted PY - 2010/2/24/entrez PY - 2010/2/24/pubmed PY - 2010/8/19/medline SP - 175 EP - 80 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 109 IS - 1-3 N2 - BACKGROUND: Stress is thought to contribute to both initiation and relapse to drug abuse. However, the mechanisms by which stress influences drug use are unclear. Interestingly, responses to acute administration of stimulant drugs resemble certain neuronal and hormonal responses to acute stress, and there is accumulating evidence that individual variation in the positive reinforcing or euphorigenic effects of a drug is related to individual differences in responsivity to acute stress. METHODS: In this study we evaluated relationships between physiological and subjective responses to a stressful task and to an oral dose of d-amphetamine in healthy adult volunteers (N=34). Individuals participated in four experimental sessions; two behavioral sessions involving a stressful task (i.e., public speech) or a non-stressful control task, and two drug sessions involving oral administration of d-amphetamine (20mg) or a placebo. The dependent measures included salivary cortisol, heart rate, mean arterial pressure, and subjective ratings of mood. RESULTS: As expected, both stress and d-amphetamine increased cortisol, heart rate and blood pressure. Stress increased negative mood, whereas d-amphetamine induced prototypic stimulant effects and increased ratings of drug liking. Analyses revealed that increased negative mood states after stress were correlated with positive mood after amphetamine. In addition, increased cortisol after stress was correlated with positive mood responses to amphetamine. Finally, there were modest positive correlations between cortisol and heart rate increases after stress and mean arterial pressure after amphetamine. CONCLUSIONS: These results support and extend previous observations that responses to acute stress are correlated with certain subjective, hormonal and cardiovascular effects of a stimulant drug. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/20176450/Stress_induced_changes_in_mood_and_cortisol_release_predict_mood_effects_of_amphetamine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(10)00039-6 DB - PRIME DP - Unbound Medicine ER -