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The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding.

Abstract

Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 mouse, and b) fat-1 mouse brain docosahexaenoic acid (22:6n-3; DHA) levels can be potentiated by fish oil feeding. Fat-1 mice and their wildtype littermates consumed either a 10% safflower oil (SO) or a 2% fish oil and 8% safflower oil chow (FO). Brain total lipid and phospholipid fraction fatty acids were analyzed using GC-FID. Wildtype mice fed FO chow had similar brain levels of DHA as fat-1 mice fed SO chow. Fat-1 mice fed FO chow had similar brain n-3 PUFA levels as fat-1 mice fed SO chow. In conclusion, brain levels of DHA in the fat-1 mouse can be obtained by and were not further augmented with fish oil feeding.

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  • Authors+Show Affiliations

    ,

    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

    , , ,

    Source

    Neurochemical research 35:5 2010 May pg 811-9

    MeSH

    Animals
    Brain
    Brain Chemistry
    Dietary Fats
    Docosahexaenoic Acids
    Fatty Acids, Omega-3
    Fatty Acids, Unsaturated
    Female
    Fish Oils
    Mice
    Mice, Transgenic
    Safflower Oil

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20177777

    Citation

    Orr, Sarah K., et al. "The Fat-1 Mouse Has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding." Neurochemical Research, vol. 35, no. 5, 2010, pp. 811-9.
    Orr SK, Tong JY, Kang JX, et al. The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochem Res. 2010;35(5):811-9.
    Orr, S. K., Tong, J. Y., Kang, J. X., Ma, D. W., & Bazinet, R. P. (2010). The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochemical Research, 35(5), pp. 811-9. doi:10.1007/s11064-010-0139-x.
    Orr SK, et al. The Fat-1 Mouse Has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding. Neurochem Res. 2010;35(5):811-9. PubMed PMID: 20177777.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. AU - Orr,Sarah K, AU - Tong,Jasmin Y M, AU - Kang,Jing X, AU - Ma,David W L, AU - Bazinet,Richard P, Y1 - 2010/02/23/ PY - 2010/02/04/accepted PY - 2010/2/24/entrez PY - 2010/2/24/pubmed PY - 2010/7/9/medline SP - 811 EP - 9 JF - Neurochemical research JO - Neurochem. Res. VL - 35 IS - 5 N2 - Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 mouse, and b) fat-1 mouse brain docosahexaenoic acid (22:6n-3; DHA) levels can be potentiated by fish oil feeding. Fat-1 mice and their wildtype littermates consumed either a 10% safflower oil (SO) or a 2% fish oil and 8% safflower oil chow (FO). Brain total lipid and phospholipid fraction fatty acids were analyzed using GC-FID. Wildtype mice fed FO chow had similar brain levels of DHA as fat-1 mice fed SO chow. Fat-1 mice fed FO chow had similar brain n-3 PUFA levels as fat-1 mice fed SO chow. In conclusion, brain levels of DHA in the fat-1 mouse can be obtained by and were not further augmented with fish oil feeding. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/20177777/The_fat_1_mouse_has_brain_docosahexaenoic_acid_levels_achievable_through_fish_oil_feeding_ L2 - https://doi.org/10.1007/s11064-010-0139-x DB - PRIME DP - Unbound Medicine ER -