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The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding.
Neurochem Res 2010; 35(5):811-9NR

Abstract

Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 mouse, and b) fat-1 mouse brain docosahexaenoic acid (22:6n-3; DHA) levels can be potentiated by fish oil feeding. Fat-1 mice and their wildtype littermates consumed either a 10% safflower oil (SO) or a 2% fish oil and 8% safflower oil chow (FO). Brain total lipid and phospholipid fraction fatty acids were analyzed using GC-FID. Wildtype mice fed FO chow had similar brain levels of DHA as fat-1 mice fed SO chow. Fat-1 mice fed FO chow had similar brain n-3 PUFA levels as fat-1 mice fed SO chow. In conclusion, brain levels of DHA in the fat-1 mouse can be obtained by and were not further augmented with fish oil feeding.

Authors+Show Affiliations

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20177777

Citation

Orr, Sarah K., et al. "The Fat-1 Mouse Has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding." Neurochemical Research, vol. 35, no. 5, 2010, pp. 811-9.
Orr SK, Tong JY, Kang JX, et al. The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochem Res. 2010;35(5):811-9.
Orr, S. K., Tong, J. Y., Kang, J. X., Ma, D. W., & Bazinet, R. P. (2010). The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochemical Research, 35(5), pp. 811-9. doi:10.1007/s11064-010-0139-x.
Orr SK, et al. The Fat-1 Mouse Has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding. Neurochem Res. 2010;35(5):811-9. PubMed PMID: 20177777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. AU - Orr,Sarah K, AU - Tong,Jasmin Y M, AU - Kang,Jing X, AU - Ma,David W L, AU - Bazinet,Richard P, Y1 - 2010/02/23/ PY - 2010/02/04/accepted PY - 2010/2/24/entrez PY - 2010/2/24/pubmed PY - 2010/7/9/medline SP - 811 EP - 9 JF - Neurochemical research JO - Neurochem. Res. VL - 35 IS - 5 N2 - Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 mouse, and b) fat-1 mouse brain docosahexaenoic acid (22:6n-3; DHA) levels can be potentiated by fish oil feeding. Fat-1 mice and their wildtype littermates consumed either a 10% safflower oil (SO) or a 2% fish oil and 8% safflower oil chow (FO). Brain total lipid and phospholipid fraction fatty acids were analyzed using GC-FID. Wildtype mice fed FO chow had similar brain levels of DHA as fat-1 mice fed SO chow. Fat-1 mice fed FO chow had similar brain n-3 PUFA levels as fat-1 mice fed SO chow. In conclusion, brain levels of DHA in the fat-1 mouse can be obtained by and were not further augmented with fish oil feeding. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/20177777/The_fat_1_mouse_has_brain_docosahexaenoic_acid_levels_achievable_through_fish_oil_feeding_ L2 - https://doi.org/10.1007/s11064-010-0139-x DB - PRIME DP - Unbound Medicine ER -