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Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats.
Food Chem Toxicol. 2010 May; 48(5):1281-7.FC

Abstract

AIM OF THE STUDY

The present study was designed to investigate the effect of bark of Pterocarpus santalinus, an ethnomedicinal plant, on blood glucose, plasma insulin, serum lipids and the activities of hepatic glucose metabolizing enzymes in streptozotocin-induced diabetic rats.

MATERIALS AND METHODS

Streptozotocin-induced diabetic rats were treated (acute/short-term and long-term) with ethyl acetate:methanol fractions of ethanolic extract of the bark of P. santalinus. Fasting blood glucose, HbA(1C), plasma insulin and protein were estimated before and after the treatment, along with hepatic glycogen, and activities of hexokinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase. Further anti-hyperlipidemic activity was studied by measuring the levels of serum lipids and lipoproteins.

RESULTS

Phytochemical analysis of active fraction showed the presence of flavonoids, glycosides and phenols. Biological testing of the active fraction demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and glycosylated hemoglobin, improving hyperlipidemia and restoring the insulin levels in treated experimental induced diabetic rats. Further elucidation of mechanism of action showed improvement in the hepatic carbohydrate metabolizing enzymes after the treatment. Our present investigation suggests that active fraction of ethanolic extract of bark of P. santalinus decreases streptozotocin induced hyperglycemia by increasing glycolysis and decreasing gluconeogenesis.

Authors+Show Affiliations

Department of Biochemistry, Sri Venkateswara University, Tirupathi, Andhra Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20178824

Citation

Kondeti, Vinay Kumar, et al. "Effect of Pterocarpus Santalinus Bark, On Blood Glucose, Serum Lipids, Plasma Insulin and Hepatic Carbohydrate Metabolic Enzymes in Streptozotocin-induced Diabetic Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 5, 2010, pp. 1281-7.
Kondeti VK, Badri KR, Maddirala DR, et al. Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2010;48(5):1281-7.
Kondeti, V. K., Badri, K. R., Maddirala, D. R., Thur, S. K., Fatima, S. S., Kasetti, R. B., & Rao, C. A. (2010). Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(5), 1281-7. https://doi.org/10.1016/j.fct.2010.02.023
Kondeti VK, et al. Effect of Pterocarpus Santalinus Bark, On Blood Glucose, Serum Lipids, Plasma Insulin and Hepatic Carbohydrate Metabolic Enzymes in Streptozotocin-induced Diabetic Rats. Food Chem Toxicol. 2010;48(5):1281-7. PubMed PMID: 20178824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. AU - Kondeti,Vinay Kumar, AU - Badri,Kameswara Rao, AU - Maddirala,Dilip Rajasekhar, AU - Thur,Sampath Kumar Mekala, AU - Fatima,Shaik Sameena, AU - Kasetti,Ramesh Babu, AU - Rao,Chippada Appa, Y1 - 2010/02/21/ PY - 2009/10/15/received PY - 2010/02/01/revised PY - 2010/02/16/accepted PY - 2010/2/25/entrez PY - 2010/2/25/pubmed PY - 2010/7/7/medline SP - 1281 EP - 7 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 48 IS - 5 N2 - AIM OF THE STUDY: The present study was designed to investigate the effect of bark of Pterocarpus santalinus, an ethnomedicinal plant, on blood glucose, plasma insulin, serum lipids and the activities of hepatic glucose metabolizing enzymes in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Streptozotocin-induced diabetic rats were treated (acute/short-term and long-term) with ethyl acetate:methanol fractions of ethanolic extract of the bark of P. santalinus. Fasting blood glucose, HbA(1C), plasma insulin and protein were estimated before and after the treatment, along with hepatic glycogen, and activities of hexokinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase. Further anti-hyperlipidemic activity was studied by measuring the levels of serum lipids and lipoproteins. RESULTS: Phytochemical analysis of active fraction showed the presence of flavonoids, glycosides and phenols. Biological testing of the active fraction demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and glycosylated hemoglobin, improving hyperlipidemia and restoring the insulin levels in treated experimental induced diabetic rats. Further elucidation of mechanism of action showed improvement in the hepatic carbohydrate metabolizing enzymes after the treatment. Our present investigation suggests that active fraction of ethanolic extract of bark of P. santalinus decreases streptozotocin induced hyperglycemia by increasing glycolysis and decreasing gluconeogenesis. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20178824/Effect_of_Pterocarpus_santalinus_bark_on_blood_glucose_serum_lipids_plasma_insulin_and_hepatic_carbohydrate_metabolic_enzymes_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(10)00124-9 DB - PRIME DP - Unbound Medicine ER -