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Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function.
Cytokine. 2010 May; 50(2):152-7.C

Abstract

Lung diseases like cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are associated with chronic airway inflammation. The aim of our study was to compare a complex biomarker profile in order to characterize specific inflammatory patterns in sputum of patients with CF and COPD. Induced sputum samples of 19 CF-, 26 COPD patients and 21 healthy controls were analyzed for concentrations of IL-1beta, IL-2, IL-6, IL-8, IL-13, IP-10, MCP-1, IFN-gamma and TNF-alpha using the new cytometric bead array (CBA) technology. Significant differences in airway biomarker profiles of CF and COPD were detected. Patients with CF showed a significant increase in IL-1beta, IL-6, IL-8, IL-13, TNF-alpha, IFN-gamma and MCP-1. COPD patients showed an increase in IL-6, IL-8, IL-13 and MCP-1 compared to healthy controls. CF and COPD compared to each other exhibited differences in IL-1beta, IL-2, IL-8, TNF-alpha, IFN-gamma and MCP-1 levels. Significant correlations between the parameters of lung function and sputum biomarker levels were found. Analyzing induced sputum allows characterization of specific airway biomarker profiles in CF and COPD and can be related to the clinical status of the patient. CBA of induced sputum seems to be a pivotal tool to characterize pulmonary inflammation.

Authors+Show Affiliations

Department of Pediatric Pulmonology, Allergy and Cystic Fibrosis, Children's Hospital, Goethe-University, Theodor-Stern-Kai 7, Frankfurt, Germany. olaf.eickmeier@kgu.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

20181491

Citation

Eickmeier, Olaf, et al. "Sputum Biomarker Profiles in Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disease (COPD) and Association Between Pulmonary Function." Cytokine, vol. 50, no. 2, 2010, pp. 152-7.
Eickmeier O, Huebner M, Herrmann E, et al. Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function. Cytokine. 2010;50(2):152-7.
Eickmeier, O., Huebner, M., Herrmann, E., Zissler, U., Rosewich, M., Baer, P. C., Buhl, R., Schmitt-Grohé, S., Zielen, S., & Schubert, R. (2010). Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function. Cytokine, 50(2), 152-7. https://doi.org/10.1016/j.cyto.2010.02.004
Eickmeier O, et al. Sputum Biomarker Profiles in Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disease (COPD) and Association Between Pulmonary Function. Cytokine. 2010;50(2):152-7. PubMed PMID: 20181491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function. AU - Eickmeier,Olaf, AU - Huebner,Marisa, AU - Herrmann,Eva, AU - Zissler,Ulrich, AU - Rosewich,Martin, AU - Baer,Patrick C, AU - Buhl,Roland, AU - Schmitt-Grohé,Sabina, AU - Zielen,Stefan, AU - Schubert,Ralf, Y1 - 2010/02/23/ PY - 2009/10/09/received PY - 2010/01/26/revised PY - 2010/02/01/accepted PY - 2010/2/26/entrez PY - 2010/2/26/pubmed PY - 2010/6/17/medline SP - 152 EP - 7 JF - Cytokine JO - Cytokine VL - 50 IS - 2 N2 - Lung diseases like cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are associated with chronic airway inflammation. The aim of our study was to compare a complex biomarker profile in order to characterize specific inflammatory patterns in sputum of patients with CF and COPD. Induced sputum samples of 19 CF-, 26 COPD patients and 21 healthy controls were analyzed for concentrations of IL-1beta, IL-2, IL-6, IL-8, IL-13, IP-10, MCP-1, IFN-gamma and TNF-alpha using the new cytometric bead array (CBA) technology. Significant differences in airway biomarker profiles of CF and COPD were detected. Patients with CF showed a significant increase in IL-1beta, IL-6, IL-8, IL-13, TNF-alpha, IFN-gamma and MCP-1. COPD patients showed an increase in IL-6, IL-8, IL-13 and MCP-1 compared to healthy controls. CF and COPD compared to each other exhibited differences in IL-1beta, IL-2, IL-8, TNF-alpha, IFN-gamma and MCP-1 levels. Significant correlations between the parameters of lung function and sputum biomarker levels were found. Analyzing induced sputum allows characterization of specific airway biomarker profiles in CF and COPD and can be related to the clinical status of the patient. CBA of induced sputum seems to be a pivotal tool to characterize pulmonary inflammation. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/20181491/Sputum_biomarker_profiles_in_cystic_fibrosis__CF__and_chronic_obstructive_pulmonary_disease__COPD__and_association_between_pulmonary_function_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(10)00030-X DB - PRIME DP - Unbound Medicine ER -