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A diet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats.
J Nutr 2010; 140(4):799-805JN

Abstract

Anticancer chemotherapy often induces side effects such as mucositis. Recent data suggest that a diet, Clinutren Protect (CP), containing whey proteins, glutamine, and transforming growth factor-beta (TGFbeta)-rich casein limits intestinal mucositis and improves recovery after a single methotrexate (MTX) challenge in rats. Chemotherapy consists of alternating periods of treatment and rest. Thus, our study evaluated the effects of CP on nutritional outcome and intestinal mucositis in rats receiving repeated chemotherapeutic challenges. Thirty-six Sprague-Dawley rats received 3 cycles of MTX at 8-d intervals. Rats had free access to CP or control diet (Co) from 7 d before the first MTX injection until the end of the experiment at d 27. In Co, whey proteins and TGFbeta-rich casein were replaced by TGFbeta-free casein. L-Glutamine was replaced by L-alanine. Body composition was assessed by dual energy X-ray absorptiometry. Before MTX challenges, food intake and body weight were similar in both groups but became higher during MTX challenges in CP (P < 0.05). Fat mass decreased similarly in both groups. In contrast, the decrease of fat free mass between d -1 and d 27 was less pronounced in the CP group (-9.5 g) than in the Co group (-57.2 g) (P < 0.05). The intestinal damage score was lower in the CP group (0.6 +/- 0.3 vs. 2.1 +/- 0.6; P < 0.05). Fecal IgA increased over time in the CP group (P < 0.05) but not in the Co group. A diet containing whey proteins, glutamine, and TGFbeta improves nutritional outcome by limiting the reduction of fat free mass and reduces intestinal mucositis during repeated chemotherapeutic challenges in rats.

Authors+Show Affiliations

Nutrition Unit, Rouen University Hospital, Rouen, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20181781

Citation

Boukhettala, Nabile, et al. "A Diet Containing Whey Protein, Free Glutamine, and Transforming Growth Factor-beta Ameliorates Nutritional Outcome and Intestinal Mucositis During Repeated Chemotherapeutic Challenges in Rats." The Journal of Nutrition, vol. 140, no. 4, 2010, pp. 799-805.
Boukhettala N, Ibrahim A, Aziz M, et al. A diet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats. J Nutr. 2010;140(4):799-805.
Boukhettala, N., Ibrahim, A., Aziz, M., Vuichoud, J., Saudan, K. Y., Blum, S., ... Coëffier, M. (2010). A diet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats. The Journal of Nutrition, 140(4), pp. 799-805. doi:10.3945/jn.109.119222.
Boukhettala N, et al. A Diet Containing Whey Protein, Free Glutamine, and Transforming Growth Factor-beta Ameliorates Nutritional Outcome and Intestinal Mucositis During Repeated Chemotherapeutic Challenges in Rats. J Nutr. 2010;140(4):799-805. PubMed PMID: 20181781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A diet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats. AU - Boukhettala,Nabile, AU - Ibrahim,Ayman, AU - Aziz,Moutaz, AU - Vuichoud,Jacques, AU - Saudan,Kim-Yen, AU - Blum,Stéphanie, AU - Déchelotte,Pierre, AU - Breuillé,Denis, AU - Coëffier,Moïse, Y1 - 2010/02/24/ PY - 2010/2/26/entrez PY - 2010/2/26/pubmed PY - 2010/5/1/medline SP - 799 EP - 805 JF - The Journal of nutrition JO - J. Nutr. VL - 140 IS - 4 N2 - Anticancer chemotherapy often induces side effects such as mucositis. Recent data suggest that a diet, Clinutren Protect (CP), containing whey proteins, glutamine, and transforming growth factor-beta (TGFbeta)-rich casein limits intestinal mucositis and improves recovery after a single methotrexate (MTX) challenge in rats. Chemotherapy consists of alternating periods of treatment and rest. Thus, our study evaluated the effects of CP on nutritional outcome and intestinal mucositis in rats receiving repeated chemotherapeutic challenges. Thirty-six Sprague-Dawley rats received 3 cycles of MTX at 8-d intervals. Rats had free access to CP or control diet (Co) from 7 d before the first MTX injection until the end of the experiment at d 27. In Co, whey proteins and TGFbeta-rich casein were replaced by TGFbeta-free casein. L-Glutamine was replaced by L-alanine. Body composition was assessed by dual energy X-ray absorptiometry. Before MTX challenges, food intake and body weight were similar in both groups but became higher during MTX challenges in CP (P < 0.05). Fat mass decreased similarly in both groups. In contrast, the decrease of fat free mass between d -1 and d 27 was less pronounced in the CP group (-9.5 g) than in the Co group (-57.2 g) (P < 0.05). The intestinal damage score was lower in the CP group (0.6 +/- 0.3 vs. 2.1 +/- 0.6; P < 0.05). Fecal IgA increased over time in the CP group (P < 0.05) but not in the Co group. A diet containing whey proteins, glutamine, and TGFbeta improves nutritional outcome by limiting the reduction of fat free mass and reduces intestinal mucositis during repeated chemotherapeutic challenges in rats. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/20181781/A_diet_containing_whey_protein_free_glutamine_and_transforming_growth_factor_beta_ameliorates_nutritional_outcome_and_intestinal_mucositis_during_repeated_chemotherapeutic_challenges_in_rats_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.119222 DB - PRIME DP - Unbound Medicine ER -