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Can nutrients prevent or delay onset of Alzheimer's disease?

Abstract

Age-related changes in nutritional status can play an important role in brain functioning. Specific nutrient deficiencies in the elderly, including omega-3 fatty acids, B-vitamins, and antioxidants among others, may exacerbate pathological processes in the brain. Consequently, the potential of nutritional intervention to prevent or delay cognitive impairment and the development of Alzheimer's disease (AD) is a topic of growing scientific interest. This review summarizes epidemiological studies linking specific nutritional deficiencies to mild cognitive impairment (MCI), as well as completed and ongoing nutritional studies in prevention of MCI and AD. Processes that underlie AD pathogenesis include: membrane/synaptic degeneration, abnormal protein processing (amyloid-beta, tau), vascular risk factors (hypertension, hypercholesterolemia), inflammation, and oxidative stress. Consideration of mechanistic evidence to date suggests that several nutritional components can effectively counteract these processes, e.g., by promoting membrane formation and synaptogenesis, enhancing memory/behavior, improving endothelial function, and cerebrovascular health. The literature reinforces the need for early intervention in AD and suggests that multi-nutritional intervention, targeting multiple aspects of the neurodegenerative process during the earliest possible phase in the development of the disease, is likely to have the greatest therapeutic potential.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands. Patrick.Kamphuis@danone.com

    Source

    MeSH

    Alzheimer Disease
    Amyloid beta-Peptides
    Antioxidants
    Brain
    Cognition Disorders
    Fatty Acids, Omega-3
    Food
    Humans
    Vitamin B Complex
    tau Proteins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    20182021

    Citation

    Kamphuis, Patrick J G H., and Philip Scheltens. "Can Nutrients Prevent or Delay Onset of Alzheimer's Disease?" Journal of Alzheimer's Disease : JAD, vol. 20, no. 3, 2010, pp. 765-75.
    Kamphuis PJ, Scheltens P. Can nutrients prevent or delay onset of Alzheimer's disease? J Alzheimers Dis. 2010;20(3):765-75.
    Kamphuis, P. J., & Scheltens, P. (2010). Can nutrients prevent or delay onset of Alzheimer's disease? Journal of Alzheimer's Disease : JAD, 20(3), pp. 765-75. doi:10.3233/JAD-2010-091558.
    Kamphuis PJ, Scheltens P. Can Nutrients Prevent or Delay Onset of Alzheimer's Disease. J Alzheimers Dis. 2010;20(3):765-75. PubMed PMID: 20182021.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Can nutrients prevent or delay onset of Alzheimer's disease? AU - Kamphuis,Patrick J G H, AU - Scheltens,Philip, PY - 2010/2/26/entrez PY - 2010/2/26/pubmed PY - 2010/9/9/medline SP - 765 EP - 75 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 20 IS - 3 N2 - Age-related changes in nutritional status can play an important role in brain functioning. Specific nutrient deficiencies in the elderly, including omega-3 fatty acids, B-vitamins, and antioxidants among others, may exacerbate pathological processes in the brain. Consequently, the potential of nutritional intervention to prevent or delay cognitive impairment and the development of Alzheimer's disease (AD) is a topic of growing scientific interest. This review summarizes epidemiological studies linking specific nutritional deficiencies to mild cognitive impairment (MCI), as well as completed and ongoing nutritional studies in prevention of MCI and AD. Processes that underlie AD pathogenesis include: membrane/synaptic degeneration, abnormal protein processing (amyloid-beta, tau), vascular risk factors (hypertension, hypercholesterolemia), inflammation, and oxidative stress. Consideration of mechanistic evidence to date suggests that several nutritional components can effectively counteract these processes, e.g., by promoting membrane formation and synaptogenesis, enhancing memory/behavior, improving endothelial function, and cerebrovascular health. The literature reinforces the need for early intervention in AD and suggests that multi-nutritional intervention, targeting multiple aspects of the neurodegenerative process during the earliest possible phase in the development of the disease, is likely to have the greatest therapeutic potential. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20182021/Can_nutrients_prevent_or_delay_onset_of_Alzheimer's_disease L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-091558 DB - PRIME DP - Unbound Medicine ER -