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Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal.
J Alzheimers Dis. 2010; 20 Suppl 1:S175-85.JA

Abstract

Alzheimer's disease has emerged in recent decades as a major health problem and the role of lifestyles in the modulation of risk has been increasingly recognized. Recent epidemiological studies suggest a protective effect for caffeine intake in dementia. We aimed to quantify the association between caffeine dietary intake and cognitive decline, in a cohort of adults living in Porto. A cohort of 648 subjects aged > or =65 years was recruited between 1999-2003. Follow-up evaluation (2005-2008) was carried out on 58.2% of the eligible participants and 10.9% were deceased. Caffeine exposure in the year preceding baseline evaluation was assessed with a validated food frequency questionnaire. Cognitive evaluation consisted of baseline and follow-up Mini-Mental State Examination (MMSE). Cognitive decline was defined by a decrease > or =2 points in the MMSE score between evaluations. Relative risk (RR) and 95% confidence interval (95%CI) estimates adjusted for age, education, smoking, alcohol drinking, body mass index, hypertension, and diabetes were computed using Poisson regression. Caffeine intake (> 62 mg/day [3rd third] vs. < 22 mg/day [1st third]) was associated with a lower risk of cognitive decline in women (RR=0.49, 95%CI 0.24-0.97), but not significantly in men (RR=0.65, 95%CI 0.27-1.54). Our study confirms the negative association between caffeine and cognitive decline in women.

Authors+Show Affiliations

Department of Hygiene and Epidemiology, Porto University Medical School and Institute of Public Health, University of Porto (ISPUP), Porto, Portugal. catarinasantos@portugalmail.ptNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20182036

Citation

Santos, Catarina, et al. "Caffeine Intake Is Associated With a Lower Risk of Cognitive Decline: a Cohort Study From Portugal." Journal of Alzheimer's Disease : JAD, vol. 20 Suppl 1, 2010, pp. S175-85.
Santos C, Lunet N, Azevedo A, et al. Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal. J Alzheimers Dis. 2010;20 Suppl 1:S175-85.
Santos, C., Lunet, N., Azevedo, A., de Mendonça, A., Ritchie, K., & Barros, H. (2010). Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal. Journal of Alzheimer's Disease : JAD, 20 Suppl 1, S175-85. https://doi.org/10.3233/JAD-2010-091303
Santos C, et al. Caffeine Intake Is Associated With a Lower Risk of Cognitive Decline: a Cohort Study From Portugal. J Alzheimers Dis. 2010;20 Suppl 1:S175-85. PubMed PMID: 20182036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal. AU - Santos,Catarina, AU - Lunet,Nuno, AU - Azevedo,Ana, AU - de Mendonça,Alexandre, AU - Ritchie,Karen, AU - Barros,Henrique, PY - 2010/2/26/entrez PY - 2010/2/26/pubmed PY - 2010/9/3/medline SP - S175 EP - 85 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 20 Suppl 1 N2 - Alzheimer's disease has emerged in recent decades as a major health problem and the role of lifestyles in the modulation of risk has been increasingly recognized. Recent epidemiological studies suggest a protective effect for caffeine intake in dementia. We aimed to quantify the association between caffeine dietary intake and cognitive decline, in a cohort of adults living in Porto. A cohort of 648 subjects aged > or =65 years was recruited between 1999-2003. Follow-up evaluation (2005-2008) was carried out on 58.2% of the eligible participants and 10.9% were deceased. Caffeine exposure in the year preceding baseline evaluation was assessed with a validated food frequency questionnaire. Cognitive evaluation consisted of baseline and follow-up Mini-Mental State Examination (MMSE). Cognitive decline was defined by a decrease > or =2 points in the MMSE score between evaluations. Relative risk (RR) and 95% confidence interval (95%CI) estimates adjusted for age, education, smoking, alcohol drinking, body mass index, hypertension, and diabetes were computed using Poisson regression. Caffeine intake (> 62 mg/day [3rd third] vs. < 22 mg/day [1st third]) was associated with a lower risk of cognitive decline in women (RR=0.49, 95%CI 0.24-0.97), but not significantly in men (RR=0.65, 95%CI 0.27-1.54). Our study confirms the negative association between caffeine and cognitive decline in women. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20182036/Caffeine_intake_is_associated_with_a_lower_risk_of_cognitive_decline:_a_cohort_study_from_Portugal_ L2 - https://medlineplus.gov/caffeine.html DB - PRIME DP - Unbound Medicine ER -