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Effect of hyperoxia on bronchial response to inhaled methacholine.
Allergy. 1991 Jan; 46(1):35-9.A

Abstract

Bronchial reactivity to methacholine (MCH) under normoxic and hyperoxic conditions was studied in a double-blind controlled study in 10 normal subjects and nine asthmatic patients. The normal volunteers were challenged while breathing dry, 21% and 100% O2, and the maximal percent falls in forced expired volume in is (FEV1) following inhalation of the highest concentration of MCH (64 mg/ml) were 8 +/- 5% and 9 +/- 8%, respectively; P = NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV1 (PC20) were 0.18 mg/ml (range 0.06-5.73) and 0.25 mg/ml (range 0.07-8.49), respectively, which were statistically not significantly different. We conclude that in humans, 100% O2 does not affect bronchial reactivity to MCH.

Authors+Show Affiliations

Internal Medicine Department, Hadassah, University Hospital, Mt. Scopus Jerusalem, Israel.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2018207

Citation

Wollner, A, et al. "Effect of Hyperoxia On Bronchial Response to Inhaled Methacholine." Allergy, vol. 46, no. 1, 1991, pp. 35-9.
Wollner A, Ben-Dov I, Bar-Yishay E. Effect of hyperoxia on bronchial response to inhaled methacholine. Allergy. 1991;46(1):35-9.
Wollner, A., Ben-Dov, I., & Bar-Yishay, E. (1991). Effect of hyperoxia on bronchial response to inhaled methacholine. Allergy, 46(1), 35-9.
Wollner A, Ben-Dov I, Bar-Yishay E. Effect of Hyperoxia On Bronchial Response to Inhaled Methacholine. Allergy. 1991;46(1):35-9. PubMed PMID: 2018207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of hyperoxia on bronchial response to inhaled methacholine. AU - Wollner,A, AU - Ben-Dov,I, AU - Bar-Yishay,E, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 35 EP - 9 JF - Allergy JO - Allergy VL - 46 IS - 1 N2 - Bronchial reactivity to methacholine (MCH) under normoxic and hyperoxic conditions was studied in a double-blind controlled study in 10 normal subjects and nine asthmatic patients. The normal volunteers were challenged while breathing dry, 21% and 100% O2, and the maximal percent falls in forced expired volume in is (FEV1) following inhalation of the highest concentration of MCH (64 mg/ml) were 8 +/- 5% and 9 +/- 8%, respectively; P = NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV1 (PC20) were 0.18 mg/ml (range 0.06-5.73) and 0.25 mg/ml (range 0.07-8.49), respectively, which were statistically not significantly different. We conclude that in humans, 100% O2 does not affect bronchial reactivity to MCH. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/2018207/Effect_of_hyperoxia_on_bronchial_response_to_inhaled_methacholine_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1991&volume=46&issue=1&spage=35 DB - PRIME DP - Unbound Medicine ER -