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Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats.
Eur J Pharmacol. 2010 May 25; 634(1-3):162-9.EJ

Abstract

Panax notoginseng saponins have recently been reported to suppress liver fibrosis. Since ginsenoside-Rg1 is the most abundant component of P.notoginseng saponins, we investigated the effect of ginsenoside-Rg1 on experimental liver fibrosis in rats. Histological analysis revealed that ginsenoside-Rg1 significantly improved the extent of liver fibrosis in rats induced by thioacetamide. Ginsenoside-Rg1 markedly suppressed the serum levels of fibrotic markers and hepatic hydroxyproline content in rats treated with thioacetamide. Ginsenoside-Rg1 also reduced the serum levels of alanine transaminase, aspartate transaminase and alkaline phosphatase. Finally, ginsenoside-Rg1 attenuated the levels of thiobarbituric acid reactive substances in livers of rats treated by thioacetamide. In cultured hepatic stellate cells, ginsenoside-Rg1 markedly inhibited cell proliferation, activation and formation of reactive oxygen species stimulated by platelet-derived growth factor-BB (PDGF-BB). Additionally, ginsenoside-Rg1 down-regulated the expression of PDGF receptor-beta by reducing the nuclear factor-kappaB activity, which was required for the gene expression. These results suggest that ginsenoside-Rg1, which exhibits its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver fibrosis.

Authors+Show Affiliations

Department of Digestive Diseases, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20184879

Citation

Geng, JiaWei, et al. "Ginsenoside-Rg1 From Panax Notoginseng Prevents Hepatic Fibrosis Induced By Thioacetamide in Rats." European Journal of Pharmacology, vol. 634, no. 1-3, 2010, pp. 162-9.
Geng J, Peng W, Huang Y, et al. Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats. Eur J Pharmacol. 2010;634(1-3):162-9.
Geng, J., Peng, W., Huang, Y., Fan, H., & Li, S. (2010). Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats. European Journal of Pharmacology, 634(1-3), 162-9. https://doi.org/10.1016/j.ejphar.2010.02.022
Geng J, et al. Ginsenoside-Rg1 From Panax Notoginseng Prevents Hepatic Fibrosis Induced By Thioacetamide in Rats. Eur J Pharmacol. 2010 May 25;634(1-3):162-9. PubMed PMID: 20184879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats. AU - Geng,JiaWei, AU - Peng,Wei, AU - Huang,YouGuang, AU - Fan,Hong, AU - Li,ShuDe, Y1 - 2010/02/23/ PY - 2009/05/26/received PY - 2010/01/29/revised PY - 2010/02/14/accepted PY - 2010/2/27/entrez PY - 2010/2/27/pubmed PY - 2010/11/3/medline SP - 162 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 634 IS - 1-3 N2 - Panax notoginseng saponins have recently been reported to suppress liver fibrosis. Since ginsenoside-Rg1 is the most abundant component of P.notoginseng saponins, we investigated the effect of ginsenoside-Rg1 on experimental liver fibrosis in rats. Histological analysis revealed that ginsenoside-Rg1 significantly improved the extent of liver fibrosis in rats induced by thioacetamide. Ginsenoside-Rg1 markedly suppressed the serum levels of fibrotic markers and hepatic hydroxyproline content in rats treated with thioacetamide. Ginsenoside-Rg1 also reduced the serum levels of alanine transaminase, aspartate transaminase and alkaline phosphatase. Finally, ginsenoside-Rg1 attenuated the levels of thiobarbituric acid reactive substances in livers of rats treated by thioacetamide. In cultured hepatic stellate cells, ginsenoside-Rg1 markedly inhibited cell proliferation, activation and formation of reactive oxygen species stimulated by platelet-derived growth factor-BB (PDGF-BB). Additionally, ginsenoside-Rg1 down-regulated the expression of PDGF receptor-beta by reducing the nuclear factor-kappaB activity, which was required for the gene expression. These results suggest that ginsenoside-Rg1, which exhibits its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver fibrosis. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/20184879/Ginsenoside_Rg1_from_Panax_notoginseng_prevents_hepatic_fibrosis_induced_by_thioacetamide_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(10)00124-X DB - PRIME DP - Unbound Medicine ER -