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Effect of artificial endolymph injection into the cochlear duct on perilymph potassium.
ORL J Otorhinolaryngol Relat Spec 2010; 71 Suppl 1:16-8OJ

Abstract

OBJECTIVE

To investigate the relationship between endolymphatic hydrops and perilymphatic potassium.

METHODS

20 pigmented guinea pigs were used: 10 for scala vestibuli study and 10 for scala tympani study. Acute endolymphatic hydrops was produced by microinjection of an artificial endolymph into the scala media. Injections were performed in the second turn at rates up to 500 nl/min for a period of 10 min. The injection volume was up to 5 microl. Endocochlear potential (EP) was monitored during injections. Simultaneous with the injections, the potassium concentrations in scala vestibuli (K(SV)) or tympani (K(ST)) perilymph were measured with ion-sensitive double-barreled microelectrodes sealed into in the scalae in the 3rd turn with cyanoacrylate glue.

RESULTS

For endolymphatic injections of <or=3 microl, perilymphatic K(SV) and K(ST) changes were generally small. With larger volume injections, substantial increases in both K(ST) and K(SV) were observed, with larger increases observed in K(SV) compared to K(ST).

CONCLUSION

An increase of perilymph potassium ion concentration is associated with endolymphatic hydrops and the perilymphatic increase could contribute to the inner ear dysfunction of patients with Ménière's disease. Although mild hydrops may not cause perilymphatic changes, extended hydrops may increase perilymphatic K which could contribute to vertigo and/or hearing loss during the attack.

Authors+Show Affiliations

Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan. kakigi-tky@umin.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20185945

Citation

Kakigi, Akinobu, et al. "Effect of Artificial Endolymph Injection Into the Cochlear Duct On Perilymph Potassium." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 71 Suppl 1, 2010, pp. 16-8.
Kakigi A, Salt AN, Takeda T. Effect of artificial endolymph injection into the cochlear duct on perilymph potassium. ORL J Otorhinolaryngol Relat Spec. 2010;71 Suppl 1:16-8.
Kakigi, A., Salt, A. N., & Takeda, T. (2010). Effect of artificial endolymph injection into the cochlear duct on perilymph potassium. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 71 Suppl 1, pp. 16-8. doi:10.1159/000265118.
Kakigi A, Salt AN, Takeda T. Effect of Artificial Endolymph Injection Into the Cochlear Duct On Perilymph Potassium. ORL J Otorhinolaryngol Relat Spec. 2010;71 Suppl 1:16-8. PubMed PMID: 20185945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of artificial endolymph injection into the cochlear duct on perilymph potassium. AU - Kakigi,Akinobu, AU - Salt,Alec N, AU - Takeda,Taizo, Y1 - 2010/02/24/ PY - 2010/2/27/entrez PY - 2010/3/10/pubmed PY - 2010/6/11/medline SP - 16 EP - 8 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 71 Suppl 1 N2 - OBJECTIVE: To investigate the relationship between endolymphatic hydrops and perilymphatic potassium. METHODS: 20 pigmented guinea pigs were used: 10 for scala vestibuli study and 10 for scala tympani study. Acute endolymphatic hydrops was produced by microinjection of an artificial endolymph into the scala media. Injections were performed in the second turn at rates up to 500 nl/min for a period of 10 min. The injection volume was up to 5 microl. Endocochlear potential (EP) was monitored during injections. Simultaneous with the injections, the potassium concentrations in scala vestibuli (K(SV)) or tympani (K(ST)) perilymph were measured with ion-sensitive double-barreled microelectrodes sealed into in the scalae in the 3rd turn with cyanoacrylate glue. RESULTS: For endolymphatic injections of <or=3 microl, perilymphatic K(SV) and K(ST) changes were generally small. With larger volume injections, substantial increases in both K(ST) and K(SV) were observed, with larger increases observed in K(SV) compared to K(ST). CONCLUSION: An increase of perilymph potassium ion concentration is associated with endolymphatic hydrops and the perilymphatic increase could contribute to the inner ear dysfunction of patients with Ménière's disease. Although mild hydrops may not cause perilymphatic changes, extended hydrops may increase perilymphatic K which could contribute to vertigo and/or hearing loss during the attack. SN - 1423-0275 UR - https://www.unboundmedicine.com/medline/citation/20185945/Effect_of_artificial_endolymph_injection_into_the_cochlear_duct_on_perilymph_potassium_ L2 - https://www.karger.com?DOI=10.1159/000265118 DB - PRIME DP - Unbound Medicine ER -