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Preventive role of PD-1 on MPTP-induced dopamine depletion in mice.
Cell Biochem Funct. 2010 Apr; 28(3):217-23.CB

Abstract

Many current studies of Parkinson's disease (PD) suggest that inflammation is involved in the neurodegenerative process. PD-1, a traditional Korean medicine, used to treat various brain diseases in Korea. This study was designed to investigate the effect of PD-1 extract in the Parkinson's model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned mice. The MPTP administration caused the dopamine neuron loss in the striatum and substantia nigra pars compacta (SNpc), which was demonstrated by a depletion of tyrosine hydroxylase (TH). In addition, a reduction of bcl-2 expression with elevation of bax expression, caspase-3 activation, and release of cytochrome c into cytosol in dopaminergic neurons of SNpc were noted. Oral administration of PD-1 extract (50 and 100 mg kg(-1)) attenuated the MPTP-induced depletion of TH proteins in the striatum and SNpc and prevented the apoptotic effects. These results indicate that PD-1 extract is able to protect dopaminergic neurons from MPTP-induced neuronal death, with important implications for the treatment of PD.

Authors+Show Affiliations

Oriental Medicine R&D Center, Dongguk University, Gyeongju, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20186864

Citation

Jung, Hyo Won, et al. "Preventive Role of PD-1 On MPTP-induced Dopamine Depletion in Mice." Cell Biochemistry and Function, vol. 28, no. 3, 2010, pp. 217-23.
Jung HW, Son HY, Jin GZ, et al. Preventive role of PD-1 on MPTP-induced dopamine depletion in mice. Cell Biochem Funct. 2010;28(3):217-23.
Jung, H. W., Son, H. Y., Jin, G. Z., & Park, Y. K. (2010). Preventive role of PD-1 on MPTP-induced dopamine depletion in mice. Cell Biochemistry and Function, 28(3), 217-23. https://doi.org/10.1002/cbf.1642
Jung HW, et al. Preventive Role of PD-1 On MPTP-induced Dopamine Depletion in Mice. Cell Biochem Funct. 2010;28(3):217-23. PubMed PMID: 20186864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventive role of PD-1 on MPTP-induced dopamine depletion in mice. AU - Jung,Hyo Won, AU - Son,Hye Young, AU - Jin,Guang-Zhen, AU - Park,Yong-Ki, PY - 2010/2/27/entrez PY - 2010/2/27/pubmed PY - 2010/6/26/medline SP - 217 EP - 23 JF - Cell biochemistry and function JO - Cell Biochem Funct VL - 28 IS - 3 N2 - Many current studies of Parkinson's disease (PD) suggest that inflammation is involved in the neurodegenerative process. PD-1, a traditional Korean medicine, used to treat various brain diseases in Korea. This study was designed to investigate the effect of PD-1 extract in the Parkinson's model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned mice. The MPTP administration caused the dopamine neuron loss in the striatum and substantia nigra pars compacta (SNpc), which was demonstrated by a depletion of tyrosine hydroxylase (TH). In addition, a reduction of bcl-2 expression with elevation of bax expression, caspase-3 activation, and release of cytochrome c into cytosol in dopaminergic neurons of SNpc were noted. Oral administration of PD-1 extract (50 and 100 mg kg(-1)) attenuated the MPTP-induced depletion of TH proteins in the striatum and SNpc and prevented the apoptotic effects. These results indicate that PD-1 extract is able to protect dopaminergic neurons from MPTP-induced neuronal death, with important implications for the treatment of PD. SN - 1099-0844 UR - https://www.unboundmedicine.com/medline/citation/20186864/Preventive_role_of_PD_1_on_MPTP_induced_dopamine_depletion_in_mice_ L2 - https://doi.org/10.1002/cbf.1642 DB - PRIME DP - Unbound Medicine ER -