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Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.
Mov Disord. 2010; 25 Suppl 1:S174-9.MD

Abstract

Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state.

Authors+Show Affiliations

Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20187238

Citation

Carta, Manolo, et al. "Role of Serotonin Neurons in the Induction of Levodopa- and Graft-induced Dyskinesias in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 25 Suppl 1, 2010, pp. S174-9.
Carta M, Carlsson T, Muñoz A, et al. Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease. Mov Disord. 2010;25 Suppl 1:S174-9.
Carta, M., Carlsson, T., Muñoz, A., Kirik, D., & Björklund, A. (2010). Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 25 Suppl 1, S174-9. https://doi.org/10.1002/mds.22792
Carta M, et al. Role of Serotonin Neurons in the Induction of Levodopa- and Graft-induced Dyskinesias in Parkinson's Disease. Mov Disord. 2010;25 Suppl 1:S174-9. PubMed PMID: 20187238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease. AU - Carta,Manolo, AU - Carlsson,Thomas, AU - Muñoz,Ana, AU - Kirik,Deniz, AU - Björklund,Anders, PY - 2010/2/27/entrez PY - 2010/2/27/pubmed PY - 2010/6/15/medline SP - S174 EP - 9 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 25 Suppl 1 N2 - Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/20187238/Role_of_serotonin_neurons_in_the_induction_of_levodopa__and_graft_induced_dyskinesias_in_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -