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Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration.
Exp Neurol. 2010 Jun; 223(2):657-61.EN

Abstract

Environmental exposures suspected of contributing to the pathophysiology of Parkinson's disease (PD) include potentially neurotoxic pesticides, which have been linked to an increased risk of PD. Conversely, possible protective factors such as the adenosine antagonist caffeine have been linked to a reduced risk of the disease. Here we assessed whether caffeine alters dopaminergic neuron loss induced by exposure to environmentally relevant pesticides (paraquat and maneb) over 8weeks. The number of nigral neurons positive for tyrosine hydroxylase immunoreactivity (TH+) was assessed using stereological methods and found to be significantly reduced (to 60% of control) by combined pesticide treatment. Caffeine at 20mg/kg significantly reduced TH+ neuron loss (to 85% of the respective control). The results demonstrate the neuroprotective potential of caffeine in a chronic pesticide exposure model of model of PD.

Authors+Show Affiliations

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20188092

Citation

Kachroo, Anil, et al. "Caffeine Protects Against Combined Paraquat and Maneb-induced Dopaminergic Neuron Degeneration." Experimental Neurology, vol. 223, no. 2, 2010, pp. 657-61.
Kachroo A, Irizarry MC, Schwarzschild MA. Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration. Exp Neurol. 2010;223(2):657-61.
Kachroo, A., Irizarry, M. C., & Schwarzschild, M. A. (2010). Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration. Experimental Neurology, 223(2), 657-61. https://doi.org/10.1016/j.expneurol.2010.02.007
Kachroo A, Irizarry MC, Schwarzschild MA. Caffeine Protects Against Combined Paraquat and Maneb-induced Dopaminergic Neuron Degeneration. Exp Neurol. 2010;223(2):657-61. PubMed PMID: 20188092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration. AU - Kachroo,Anil, AU - Irizarry,Michael C, AU - Schwarzschild,Michael A, Y1 - 2010/02/24/ PY - 2009/12/17/received PY - 2010/02/05/revised PY - 2010/02/14/accepted PY - 2010/3/2/entrez PY - 2010/3/2/pubmed PY - 2010/7/2/medline SP - 657 EP - 61 JF - Experimental neurology JO - Exp Neurol VL - 223 IS - 2 N2 - Environmental exposures suspected of contributing to the pathophysiology of Parkinson's disease (PD) include potentially neurotoxic pesticides, which have been linked to an increased risk of PD. Conversely, possible protective factors such as the adenosine antagonist caffeine have been linked to a reduced risk of the disease. Here we assessed whether caffeine alters dopaminergic neuron loss induced by exposure to environmentally relevant pesticides (paraquat and maneb) over 8weeks. The number of nigral neurons positive for tyrosine hydroxylase immunoreactivity (TH+) was assessed using stereological methods and found to be significantly reduced (to 60% of control) by combined pesticide treatment. Caffeine at 20mg/kg significantly reduced TH+ neuron loss (to 85% of the respective control). The results demonstrate the neuroprotective potential of caffeine in a chronic pesticide exposure model of model of PD. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/20188092/Caffeine_protects_against_combined_paraquat_and_maneb_induced_dopaminergic_neuron_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(10)00062-2 DB - PRIME DP - Unbound Medicine ER -