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Prevalence and risk factors for primary glaucomas in adult urban and rural populations in the Andhra Pradesh Eye Disease Study.
Ophthalmology 2010; 117(7):1352-9O

Abstract

PURPOSE

To compare the prevalence of and risk factors for primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) in urban and rural populations in the Andhra Pradesh Eye Disease Study.

DESIGN

A population-based, cross-sectional study using a stratified, random, cluster, and systematic sampling strategy.

PARTICIPANTS

Between 1996 and 2000, participants from 94 clusters in 1 urban and 3 rural areas representative of the population were included.

METHODS

We performed a detailed eye examination, including applanation tonometry, gonioscopy, and dilated fundus evaluation after ruling out risk of angle closure. Humphrey threshold 24-2 visual fields were performed when indicated.

MAIN OUTCOME MEASURES

Glaucoma was diagnosed and categorized using International Society of Geographical and Epidemiological Ophthalmology criteria. The prevalence and risk factors for POAG and PACG in subjects aged > or = 40 years were compared between the urban and rural cohorts.

RESULTS

There were 3724 subjects > or = 40 years, with 934 in the urban and 2790 in the rural cohort. The prevalence of POAG was greater in the urban compared with the rural cohort (4% vs 1.6%; P<0.001). Age and intraocular pressure (IOP) were risk factors for POAG in both cohorts. Blindness owing to POAG was 11.1% in the rural and 2.7% in the urban cohort. The prevalence of PACG (1.8% vs 0.7%; P<0.01), primary angle closure (PAC) (0.8% vs 0.2%; P = 0.02) and primary angle closure suspect (PACS; 3.5% vs 1.5%; P<0.01) were significantly different between the urban and rural cohorts. Increasing age was a risk factor in the urban cohort. Intraocular pressure was a risk factor in both the populations. Blindness owing to PACG was equal (20%) in both the populations. Female gender was a risk factor in the rural cohort (P = 0.032).

CONCLUSIONS

The prevalence of both POAG and PACG was greater in urban than in the rural population. Intraocular pressure was a significant risk factor for both POAG and PACG in both cohorts. Increasing age was a significant risk factor for POAG in both cohorts and for PACG in the urban cohort. Female gender was a risk factor for PACG in the rural cohort. There was more blindness owing to PACG than to POAG.

FINANCIAL DISCLOSURE(S)

The authors have no proprietary or commercial interest in any of the materials discussed in this article.

Authors+Show Affiliations

L. V. Prasad Eye Institute, Kallam Anji Reddy campus, Banjara Hills, Hyderabad, India. gcs@lvpei.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20188420

Citation

Garudadri, Chandrasekhar, et al. "Prevalence and Risk Factors for Primary Glaucomas in Adult Urban and Rural Populations in the Andhra Pradesh Eye Disease Study." Ophthalmology, vol. 117, no. 7, 2010, pp. 1352-9.
Garudadri C, Senthil S, Khanna RC, et al. Prevalence and risk factors for primary glaucomas in adult urban and rural populations in the Andhra Pradesh Eye Disease Study. Ophthalmology. 2010;117(7):1352-9.
Garudadri, C., Senthil, S., Khanna, R. C., Sannapaneni, K., & Rao, H. B. (2010). Prevalence and risk factors for primary glaucomas in adult urban and rural populations in the Andhra Pradesh Eye Disease Study. Ophthalmology, 117(7), pp. 1352-9. doi:10.1016/j.ophtha.2009.11.006.
Garudadri C, et al. Prevalence and Risk Factors for Primary Glaucomas in Adult Urban and Rural Populations in the Andhra Pradesh Eye Disease Study. Ophthalmology. 2010;117(7):1352-9. PubMed PMID: 20188420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors for primary glaucomas in adult urban and rural populations in the Andhra Pradesh Eye Disease Study. AU - Garudadri,Chandrasekhar, AU - Senthil,Sirisha, AU - Khanna,Rohit C, AU - Sannapaneni,Krishniah, AU - Rao,Harsha B Laxmana, Y1 - 2010/02/25/ PY - 2009/03/31/received PY - 2009/10/30/revised PY - 2009/11/03/accepted PY - 2010/3/2/entrez PY - 2010/3/2/pubmed PY - 2010/7/22/medline SP - 1352 EP - 9 JF - Ophthalmology JO - Ophthalmology VL - 117 IS - 7 N2 - PURPOSE: To compare the prevalence of and risk factors for primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) in urban and rural populations in the Andhra Pradesh Eye Disease Study. DESIGN: A population-based, cross-sectional study using a stratified, random, cluster, and systematic sampling strategy. PARTICIPANTS: Between 1996 and 2000, participants from 94 clusters in 1 urban and 3 rural areas representative of the population were included. METHODS: We performed a detailed eye examination, including applanation tonometry, gonioscopy, and dilated fundus evaluation after ruling out risk of angle closure. Humphrey threshold 24-2 visual fields were performed when indicated. MAIN OUTCOME MEASURES: Glaucoma was diagnosed and categorized using International Society of Geographical and Epidemiological Ophthalmology criteria. The prevalence and risk factors for POAG and PACG in subjects aged > or = 40 years were compared between the urban and rural cohorts. RESULTS: There were 3724 subjects > or = 40 years, with 934 in the urban and 2790 in the rural cohort. The prevalence of POAG was greater in the urban compared with the rural cohort (4% vs 1.6%; P<0.001). Age and intraocular pressure (IOP) were risk factors for POAG in both cohorts. Blindness owing to POAG was 11.1% in the rural and 2.7% in the urban cohort. The prevalence of PACG (1.8% vs 0.7%; P<0.01), primary angle closure (PAC) (0.8% vs 0.2%; P = 0.02) and primary angle closure suspect (PACS; 3.5% vs 1.5%; P<0.01) were significantly different between the urban and rural cohorts. Increasing age was a risk factor in the urban cohort. Intraocular pressure was a risk factor in both the populations. Blindness owing to PACG was equal (20%) in both the populations. Female gender was a risk factor in the rural cohort (P = 0.032). CONCLUSIONS: The prevalence of both POAG and PACG was greater in urban than in the rural population. Intraocular pressure was a significant risk factor for both POAG and PACG in both cohorts. Increasing age was a significant risk factor for POAG in both cohorts and for PACG in the urban cohort. Female gender was a risk factor for PACG in the rural cohort. There was more blindness owing to PACG than to POAG. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any of the materials discussed in this article. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/20188420/Prevalence_and_risk_factors_for_primary_glaucomas_in_adult_urban_and_rural_populations_in_the_Andhra_Pradesh_Eye_Disease_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(09)01294-9 DB - PRIME DP - Unbound Medicine ER -