Tags

Type your tag names separated by a space and hit enter

Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun; 82(4-6):305-14.PL

Abstract

Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) are critical for infant and childhood brain development, but levels of the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are often low in the Western diet. Increasing evidence from both epidemiological and intervention studies, reviewed here, indicates that DHA supplementation, during pregnancy, lactation, or childhood plays an important role in childhood neurodevelopment. Arachidonic acid (ARA) is also important for infant growth and development. Several studies have demonstrated positive associations between blood DHA levels and improvements on tests of cognitive and visual function in healthy children. Controlled trials also have shown that supplementation with DHA and EPA may help in the management of childhood psychiatric disorders, and improve visual and motor functions in children with phenylketonuria. In all studies, DHA and EPA supplementation is typically well tolerated. Further research is needed to determine optimal doses for efficacy at different developmental ages. The potential long-term benefits of early LCPUFA supplementation also require consideration.

Authors+Show Affiliations

Martek Biosciences Corporation, Columbia, MD 21045, USA. alryan@martek.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20188533

Citation

Ryan, Alan S., et al. "Effects of Long-chain Polyunsaturated Fatty Acid Supplementation On Neurodevelopment in Childhood: a Review of Human Studies." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 82, no. 4-6, 2010, pp. 305-14.
Ryan AS, Astwood JD, Gautier S, et al. Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids. 2010;82(4-6):305-14.
Ryan, A. S., Astwood, J. D., Gautier, S., Kuratko, C. N., Nelson, E. B., & Salem, N. (2010). Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 82(4-6), 305-14. https://doi.org/10.1016/j.plefa.2010.02.007
Ryan AS, et al. Effects of Long-chain Polyunsaturated Fatty Acid Supplementation On Neurodevelopment in Childhood: a Review of Human Studies. Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):305-14. PubMed PMID: 20188533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. AU - Ryan,Alan S, AU - Astwood,James D, AU - Gautier,Sheila, AU - Kuratko,Connye N, AU - Nelson,Edward B, AU - Salem,Norman,Jr Y1 - 2010/02/25/ PY - 2010/3/2/entrez PY - 2010/3/2/pubmed PY - 2010/8/12/medline SP - 305 EP - 14 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 82 IS - 4-6 N2 - Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) are critical for infant and childhood brain development, but levels of the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are often low in the Western diet. Increasing evidence from both epidemiological and intervention studies, reviewed here, indicates that DHA supplementation, during pregnancy, lactation, or childhood plays an important role in childhood neurodevelopment. Arachidonic acid (ARA) is also important for infant growth and development. Several studies have demonstrated positive associations between blood DHA levels and improvements on tests of cognitive and visual function in healthy children. Controlled trials also have shown that supplementation with DHA and EPA may help in the management of childhood psychiatric disorders, and improve visual and motor functions in children with phenylketonuria. In all studies, DHA and EPA supplementation is typically well tolerated. Further research is needed to determine optimal doses for efficacy at different developmental ages. The potential long-term benefits of early LCPUFA supplementation also require consideration. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/20188533/Effects_of_long_chain_polyunsaturated_fatty_acid_supplementation_on_neurodevelopment_in_childhood:_a_review_of_human_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(10)00051-7 DB - PRIME DP - Unbound Medicine ER -