Abstract
Herein, an electrochemical differential pulse voltammetric method was developed for the determination of moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate. The oxidation process has been carried out in Britton-Robinson buffer. Moexipril hydrochloride exhibits a well-defined irreversible oxidation peak over the entire pH range (2-11). The peak current varied linearly over the range from 4.0 x 10(-7) to 5.2 x 10(-6) mol L(-1). The limits of detection and quantification were 6.87 x 10(-8) mol L(-1) and 2.29 x 10(-7) mol L(-1), respectively. The recovery was found in the range from 99.65% to 100.76%. The relative standard deviation was found in the range from 0.429% to 0.845%. The proposed method possesses high sensitivity, accuracy and rapid response. Finally, this method was successfully used to determine moexipril hydrochloride in tablets.
TY - JOUR
T1 - Determination of antihypertensive drug moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate at carbon paste electrode.
A1 - Attia,Ali K,
Y1 - 2009/11/13/
PY - 2009/07/02/received
PY - 2009/11/05/revised
PY - 2009/11/09/accepted
PY - 2010/3/2/entrez
PY - 2010/3/2/pubmed
PY - 2010/5/21/medline
SP - 25
EP - 9
JF - Talanta
JO - Talanta
VL - 81
IS - 1-2
N2 - Herein, an electrochemical differential pulse voltammetric method was developed for the determination of moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate. The oxidation process has been carried out in Britton-Robinson buffer. Moexipril hydrochloride exhibits a well-defined irreversible oxidation peak over the entire pH range (2-11). The peak current varied linearly over the range from 4.0 x 10(-7) to 5.2 x 10(-6) mol L(-1). The limits of detection and quantification were 6.87 x 10(-8) mol L(-1) and 2.29 x 10(-7) mol L(-1), respectively. The recovery was found in the range from 99.65% to 100.76%. The relative standard deviation was found in the range from 0.429% to 0.845%. The proposed method possesses high sensitivity, accuracy and rapid response. Finally, this method was successfully used to determine moexipril hydrochloride in tablets.
SN - 1873-3573
UR - https://www.unboundmedicine.com/medline/citation/20188882/Determination_of_antihypertensive_drug_moexipril_hydrochloride_based_on_the_enhancement_effect_of_sodium_dodecyl_sulfate_at_carbon_paste_electrode_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(09)00880-7
DB - PRIME
DP - Unbound Medicine
ER -