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Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study.

Abstract

OBJECTIVE

To evaluate the effect of metformin in polycystic ovary syndrome (PCOS). As follow-up on a previous paper describing hormonal and metabolic factors, this paper focuses on correlations between adiponectin and anthropometric, hormonal, and metabolic factors in PCOS and the effect of metformin.

DESIGN

Randomized, double-blind, placebo-controlled crossover study.

SETTING

District and university hospital.

PATIENT(S)

Fifty-two women with PCOS. Three groups were defined according to baseline adiponectin.

INTERVENTION(S)

Metformin or placebo for 6 months, followed by 3 months' washout before switching to opposite treatment. Blood tests and measurements were performed before and after treatment periods.

MAIN OUTCOME MEASURE(S)

Adiponectin, insulin, homeostasis model assessment (HOMA) index, and testosterone.

RESULT(S)

Waist-hip ratio (WHR), insulin, and HOMA index were significantly higher in the lower adiponectin group than in the upper and middle group, and high-density lipoprotein (HDL) cholesterol was higher in the upper than in the lower adiponectin group. Multiple regression analysis with adiponectin as the dependent variable and HOMA index, HDL cholesterol, testosterone, and WHR as independent variables showed an R(2) of 0.43 with β-coefficients of -0.12 for the HOMA index, 0.72 for HDL cholesterol, and -1.49 for WHR. Testosterone did not contribute to the prediction of adiponectin levels. Metformin had no effect on adiponectin in spite of significant decreases in weight, fasting glucose, and insulin resistance.

CONCLUSION(S)

In PCOS, adiponectin levels are closely linked to insulin resistance, HDL cholesterol, and abdominal adiposity and unaffected by metformin.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynaecology, Aarhus University Hospital, Skejby, Denmark. ditte.trolle@dadlnet.dk

    , ,

    Source

    Fertility and sterility 94:6 2010 Nov pg 2234-8

    MeSH

    Adiponectin
    Adolescent
    Adult
    Cross-Over Studies
    Double-Blind Method
    Female
    Humans
    Hypoglycemic Agents
    Insulin
    Insulin Resistance
    Metformin
    Middle Aged
    Placebos
    Polycystic Ovary Syndrome
    Testosterone
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    20189560

    Citation

    Trolle, Birgitta, et al. "Adiponectin Levels in Women With Polycystic Ovary Syndrome: Impact of Metformin Treatment in a Randomized Controlled Study." Fertility and Sterility, vol. 94, no. 6, 2010, pp. 2234-8.
    Trolle B, Lauszus FF, Frystyk J, et al. Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study. Fertil Steril. 2010;94(6):2234-8.
    Trolle, B., Lauszus, F. F., Frystyk, J., & Flyvbjerg, A. (2010). Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study. Fertility and Sterility, 94(6), pp. 2234-8. doi:10.1016/j.fertnstert.2010.01.057.
    Trolle B, et al. Adiponectin Levels in Women With Polycystic Ovary Syndrome: Impact of Metformin Treatment in a Randomized Controlled Study. Fertil Steril. 2010;94(6):2234-8. PubMed PMID: 20189560.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study. AU - Trolle,Birgitta, AU - Lauszus,Finn Friis, AU - Frystyk,Jan, AU - Flyvbjerg,Allan, Y1 - 2010/03/02/ PY - 2009/09/01/received PY - 2010/01/15/revised PY - 2010/01/21/accepted PY - 2010/3/2/entrez PY - 2010/3/2/pubmed PY - 2010/12/14/medline SP - 2234 EP - 8 JF - Fertility and sterility JO - Fertil. Steril. VL - 94 IS - 6 N2 - OBJECTIVE: To evaluate the effect of metformin in polycystic ovary syndrome (PCOS). As follow-up on a previous paper describing hormonal and metabolic factors, this paper focuses on correlations between adiponectin and anthropometric, hormonal, and metabolic factors in PCOS and the effect of metformin. DESIGN: Randomized, double-blind, placebo-controlled crossover study. SETTING: District and university hospital. PATIENT(S): Fifty-two women with PCOS. Three groups were defined according to baseline adiponectin. INTERVENTION(S): Metformin or placebo for 6 months, followed by 3 months' washout before switching to opposite treatment. Blood tests and measurements were performed before and after treatment periods. MAIN OUTCOME MEASURE(S): Adiponectin, insulin, homeostasis model assessment (HOMA) index, and testosterone. RESULT(S): Waist-hip ratio (WHR), insulin, and HOMA index were significantly higher in the lower adiponectin group than in the upper and middle group, and high-density lipoprotein (HDL) cholesterol was higher in the upper than in the lower adiponectin group. Multiple regression analysis with adiponectin as the dependent variable and HOMA index, HDL cholesterol, testosterone, and WHR as independent variables showed an R(2) of 0.43 with β-coefficients of -0.12 for the HOMA index, 0.72 for HDL cholesterol, and -1.49 for WHR. Testosterone did not contribute to the prediction of adiponectin levels. Metformin had no effect on adiponectin in spite of significant decreases in weight, fasting glucose, and insulin resistance. CONCLUSION(S): In PCOS, adiponectin levels are closely linked to insulin resistance, HDL cholesterol, and abdominal adiposity and unaffected by metformin. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/20189560/Adiponectin_levels_in_women_with_polycystic_ovary_syndrome:_impact_of_metformin_treatment_in_a_randomized_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(10)00132-9 DB - PRIME DP - Unbound Medicine ER -