Citation
de Sá, Larissa Bianca Paiva Cunha, et al. "Effects of Ghrelin, Growth Hormone-releasing Peptide-6, and Growth Hormone-releasing Hormone On Growth Hormone, Adrenocorticotropic Hormone, and Cortisol Release in Type 1 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 59, no. 10, 2010, pp. 1536-42.
de Sá LB, Nascif SO, Correa-Silva SR, et al. Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus. Metabolism. 2010;59(10):1536-42.
de Sá, L. B., Nascif, S. O., Correa-Silva, S. R., Molica, P., Vieira, J. G., Dib, S. A., & Lengyel, A. M. (2010). Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus. Metabolism: Clinical and Experimental, 59(10), 1536-42. https://doi.org/10.1016/j.metabol.2010.01.021
de Sá LB, et al. Effects of Ghrelin, Growth Hormone-releasing Peptide-6, and Growth Hormone-releasing Hormone On Growth Hormone, Adrenocorticotropic Hormone, and Cortisol Release in Type 1 Diabetes Mellitus. Metabolism. 2010;59(10):1536-42. PubMed PMID: 20189610.
TY - JOUR
T1 - Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus.
AU - de Sá,Larissa Bianca Paiva Cunha,
AU - Nascif,Sergio Oliva,
AU - Correa-Silva,Silvia Regina,
AU - Molica,Patricia,
AU - Vieira,José Gilberto Henriques,
AU - Dib,Sergio Atala,
AU - Lengyel,Ana-Maria Judith,
Y1 - 2010/03/01/
PY - 2009/10/11/received
PY - 2010/01/20/revised
PY - 2010/01/22/accepted
PY - 2010/3/2/entrez
PY - 2010/3/2/pubmed
PY - 2010/10/28/medline
SP - 1536
EP - 42
JF - Metabolism: clinical and experimental
JO - Metabolism
VL - 59
IS - 10
N2 - In type 1 diabetes mellitus (T1DM), growth hormone (GH) responses to provocative stimuli are normal or exaggerated, whereas the hypothalamic-pituitary-adrenal axis has been less studied. Ghrelin is a GH secretagogue that also increases adrenocorticotropic hormone (ACTH) and cortisol levels, similarly to GH-releasing peptide-6 (GHRP-6). Ghrelin's effects in patients with T1DM have not been evaluated. We therefore studied GH, ACTH, and cortisol responses to ghrelin and GHRP-6 in 9 patients with T1DM and 9 control subjects. The GH-releasing hormone (GHRH)-induced GH release was also evaluated. Mean fasting GH levels (micrograms per liter) were higher in T1DM (3.5 ± 1.2) than in controls (0.6 ± 0.3). In both groups, ghrelin-induced GH release was higher than that after GHRP-6 and GHRH. When analyzing Δ area under the curve (ΔAUC) GH values after ghrelin, GHRP-6, and GHRH, no significant differences were observed in T1DM compared with controls. There was a trend (P = .055) to higher mean basal cortisol values (micrograms per deciliter) in T1DM (11.7 ± 1.5) compared with controls (8.2 ± 0.8). No significant differences were seen in ΔAUC cortisol values in both groups after ghrelin and GHRP-6. Mean fasting ACTH values were similar in T1DM and controls. No differences were seen in ΔAUC ACTH levels in both groups after ghrelin and GHRP-6. In summary, patients with T1DM have normal GH responsiveness to ghrelin, GHRP-6, and GHRH. The ACTH and cortisol release after ghrelin and GHRP-6 is also similar to controls. Our results suggest that chronic hyperglycemia of T1DM does not interfere with GH-, ACTH-, and cortisol-releasing mechanisms stimulated by these peptides.
SN - 1532-8600
UR - https://www.unboundmedicine.com/medline/citation/20189610/Effects_of_ghrelin_growth_hormone_releasing_peptide_6_and_growth_hormone_releasing_hormone_on_growth_hormone_adrenocorticotropic_hormone_and_cortisol_release_in_type_1_diabetes_mellitus_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(10)00036-3
DB - PRIME
DP - Unbound Medicine
ER -