TY - JOUR T1 - Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus. AU - de Sá,Larissa Bianca Paiva Cunha, AU - Nascif,Sergio Oliva, AU - Correa-Silva,Silvia Regina, AU - Molica,Patricia, AU - Vieira,José Gilberto Henriques, AU - Dib,Sergio Atala, AU - Lengyel,Ana-Maria Judith, Y1 - 2010/03/01/ PY - 2009/10/11/received PY - 2010/01/20/revised PY - 2010/01/22/accepted PY - 2010/3/2/entrez PY - 2010/3/2/pubmed PY - 2010/10/28/medline SP - 1536 EP - 42 JF - Metabolism: clinical and experimental JO - Metabolism VL - 59 IS - 10 N2 - In type 1 diabetes mellitus (T1DM), growth hormone (GH) responses to provocative stimuli are normal or exaggerated, whereas the hypothalamic-pituitary-adrenal axis has been less studied. Ghrelin is a GH secretagogue that also increases adrenocorticotropic hormone (ACTH) and cortisol levels, similarly to GH-releasing peptide-6 (GHRP-6). Ghrelin's effects in patients with T1DM have not been evaluated. We therefore studied GH, ACTH, and cortisol responses to ghrelin and GHRP-6 in 9 patients with T1DM and 9 control subjects. The GH-releasing hormone (GHRH)-induced GH release was also evaluated. Mean fasting GH levels (micrograms per liter) were higher in T1DM (3.5 ± 1.2) than in controls (0.6 ± 0.3). In both groups, ghrelin-induced GH release was higher than that after GHRP-6 and GHRH. When analyzing Δ area under the curve (ΔAUC) GH values after ghrelin, GHRP-6, and GHRH, no significant differences were observed in T1DM compared with controls. There was a trend (P = .055) to higher mean basal cortisol values (micrograms per deciliter) in T1DM (11.7 ± 1.5) compared with controls (8.2 ± 0.8). No significant differences were seen in ΔAUC cortisol values in both groups after ghrelin and GHRP-6. Mean fasting ACTH values were similar in T1DM and controls. No differences were seen in ΔAUC ACTH levels in both groups after ghrelin and GHRP-6. In summary, patients with T1DM have normal GH responsiveness to ghrelin, GHRP-6, and GHRH. The ACTH and cortisol release after ghrelin and GHRP-6 is also similar to controls. Our results suggest that chronic hyperglycemia of T1DM does not interfere with GH-, ACTH-, and cortisol-releasing mechanisms stimulated by these peptides. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/20189610/Effects_of_ghrelin_growth_hormone_releasing_peptide_6_and_growth_hormone_releasing_hormone_on_growth_hormone_adrenocorticotropic_hormone_and_cortisol_release_in_type_1_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(10)00036-3 DB - PRIME DP - Unbound Medicine ER -