Tags

Type your tag names separated by a space and hit enter

The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt.
Trans R Soc Trop Med Hyg. 2010 Jun; 104(6):429-32.TR

Abstract

Insulin-like growth factor 1 (IGF-1) levels have been found to correlate with measurements of bone mineral density (BMD) in liver diseases. This study investigated the relationship between IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3) and BMD in patients with chronic hepatitis C virus. This study was conducted for 30 patients with chronic hepatitis C virus infection (16 patients without and 14 patients with cirrhosis) and 11 healthy controls. Serum levels of IGF-1 and IGFBP-3 and BMD of the proximal femur and lumbar spine were measured in all subjects. Osteoporosis of the proximal femur and lumbar spine was found in 42.9% and 21.4%, respectively, of the patients with cirrhosis. Patients with liver cirrhosis and osteoporosis of the proximal femur and lumbar spine had lower IGF-1 (P<0.001, P=0.04, P=0.04 respectively). BMD of the proximal femur was lower in cirrhotic patients compared with controls (P<0.01). Patients with liver cirrhosis had lower IGFBP-3 than patients without cirrhosis and controls (P<0.001). Patients with osteoporosis of the proximal femur had lower IGFBP-3 than those without osteoporosis (P<0.01). IGF-1 and IGFBP-3 levels were lower in patients with liver cirrhosis. IGF-1 and IGFBP-3 may play a role in hepatic osteoporosis.

Authors+Show Affiliations

Internal Medicine Department, National Research Centre, El Buhoth Street, Dokki, Cairo, 12311, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20189618

Citation

Raslan, Hala M., et al. "The Potential Role of Insulin-like Growth Factor 1, Insulin-like Growth Factor Binding Protein 3 and Bone Mineral Density in Patients With Chronic Hepatitis C Virus in Cairo, Egypt." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 104, no. 6, 2010, pp. 429-32.
Raslan HM, Elhosary Y, Ezzat WM, et al. The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt. Trans R Soc Trop Med Hyg. 2010;104(6):429-32.
Raslan, H. M., Elhosary, Y., Ezzat, W. M., Rasheed, E. A., & Rasheed, M. A. (2010). The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(6), 429-32. https://doi.org/10.1016/j.trstmh.2010.01.012
Raslan HM, et al. The Potential Role of Insulin-like Growth Factor 1, Insulin-like Growth Factor Binding Protein 3 and Bone Mineral Density in Patients With Chronic Hepatitis C Virus in Cairo, Egypt. Trans R Soc Trop Med Hyg. 2010;104(6):429-32. PubMed PMID: 20189618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt. AU - Raslan,Hala M, AU - Elhosary,Yasser, AU - Ezzat,Wafaa M, AU - Rasheed,Enas Abdel, AU - Rasheed,Maha A, Y1 - 2010/03/01/ PY - 2009/05/21/received PY - 2010/01/18/revised PY - 2010/01/18/accepted PY - 2010/3/2/entrez PY - 2010/3/2/pubmed PY - 2010/9/18/medline SP - 429 EP - 32 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 104 IS - 6 N2 - Insulin-like growth factor 1 (IGF-1) levels have been found to correlate with measurements of bone mineral density (BMD) in liver diseases. This study investigated the relationship between IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3) and BMD in patients with chronic hepatitis C virus. This study was conducted for 30 patients with chronic hepatitis C virus infection (16 patients without and 14 patients with cirrhosis) and 11 healthy controls. Serum levels of IGF-1 and IGFBP-3 and BMD of the proximal femur and lumbar spine were measured in all subjects. Osteoporosis of the proximal femur and lumbar spine was found in 42.9% and 21.4%, respectively, of the patients with cirrhosis. Patients with liver cirrhosis and osteoporosis of the proximal femur and lumbar spine had lower IGF-1 (P<0.001, P=0.04, P=0.04 respectively). BMD of the proximal femur was lower in cirrhotic patients compared with controls (P<0.01). Patients with liver cirrhosis had lower IGFBP-3 than patients without cirrhosis and controls (P<0.001). Patients with osteoporosis of the proximal femur had lower IGFBP-3 than those without osteoporosis (P<0.01). IGF-1 and IGFBP-3 levels were lower in patients with liver cirrhosis. IGF-1 and IGFBP-3 may play a role in hepatic osteoporosis. SN - 1878-3503 UR - https://www.unboundmedicine.com/medline/citation/20189618/The_potential_role_of_insulin_like_growth_factor_1_insulin_like_growth_factor_binding_protein_3_and_bone_mineral_density_in_patients_with_chronic_hepatitis_C_virus_in_Cairo_Egypt_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(10)00031-3 DB - PRIME DP - Unbound Medicine ER -