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Flavonol quantification and stability of phenolics in fermented extracts from fresh Betula pendula leaves.
J Pharm Biomed Anal. 2010 Oct 10; 53(2):137-44.JP

Abstract

An HPLC method, which allows reliable quantitation of flavonols and other phenolics in birch leaf extracts, was developed and validated. The method was applied to study the bioconversion of flavonols in fermented aqueous extracts. Almost 100% of the flavonols were converted during the 12 months observation period. The generated phenolics as well as consecutive conversion products were identified by HPLC-DAD, LC-MS and GC-MS techniques.

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Authors+Show Affiliations

Millet A
Institute for Pharmaceutical Sciences, Department of Pharmaceutical Biology and Biotechnology, Albert-Ludwig-University Freiburg, Stefan-Meier-Strasse 19, 79104 Freiburg, Germany.
Stintzing F
No affiliation info available
Merfort I
No affiliation info available

MeSH

BetulaChromatography, High Pressure LiquidChromatography, LiquidDrug StabilityFermentationFlavonolsMass SpectrometryModels, ChemicalPhenolsPlant ExtractsPlant LeavesQuercetin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

20189738

Citation

Millet, Agnès, et al. "Flavonol Quantification and Stability of Phenolics in Fermented Extracts From Fresh Betula Pendula Leaves." Journal of Pharmaceutical and Biomedical Analysis, vol. 53, no. 2, 2010, pp. 137-44.
Millet A, Stintzing F, Merfort I. Flavonol quantification and stability of phenolics in fermented extracts from fresh Betula pendula leaves. J Pharm Biomed Anal. 2010;53(2):137-44.
Millet, A., Stintzing, F., & Merfort, I. (2010). Flavonol quantification and stability of phenolics in fermented extracts from fresh Betula pendula leaves. Journal of Pharmaceutical and Biomedical Analysis, 53(2), 137-44. https://doi.org/10.1016/j.jpba.2010.02.001
Millet A, Stintzing F, Merfort I. Flavonol Quantification and Stability of Phenolics in Fermented Extracts From Fresh Betula Pendula Leaves. J Pharm Biomed Anal. 2010 Oct 10;53(2):137-44. PubMed PMID: 20189738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonol quantification and stability of phenolics in fermented extracts from fresh Betula pendula leaves. AU - Millet,Agnès, AU - Stintzing,Florian, AU - Merfort,Irmgard, Y1 - 2010/02/07/ PY - 2009/11/16/received PY - 2010/01/14/revised PY - 2010/02/01/accepted PY - 2010/3/2/entrez PY - 2010/3/2/pubmed PY - 2010/10/15/medline SP - 137 EP - 44 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 53 IS - 2 N2 - An HPLC method, which allows reliable quantitation of flavonols and other phenolics in birch leaf extracts, was developed and validated. The method was applied to study the bioconversion of flavonols in fermented aqueous extracts. Almost 100% of the flavonols were converted during the 12 months observation period. The generated phenolics as well as consecutive conversion products were identified by HPLC-DAD, LC-MS and GC-MS techniques. SN - 1873-264X UR - https://www.unboundmedicine.com/medline/citation/20189738/Flavonol_quantification_and_stability_of_phenolics_in_fermented_extracts_from_fresh_Betula_pendula_leaves_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(10)00070-1 DB - PRIME DP - Unbound Medicine ER -