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First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells.
J Agric Food Chem. 2010 Mar 24; 58(6):3366-70.JA

Abstract

The present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC(50) = 239.7 +/- 43.2 microg/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 microg/mL). The antiproliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent.

Authors+Show Affiliations

CEBIMED/Research Group on Toxicology and Phytochemistry, Faculty of Health Sciences, University Fernando Pessoa, R. Carlos da Maia, Porto, Portugal. mcarv@ufp.edu.ptNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20192210

Citation

Carvalho, Márcia, et al. "First Report On Cydonia Oblonga Miller Anticancer Potential: Differential Antiproliferative Effect Against Human Kidney and Colon Cancer Cells." Journal of Agricultural and Food Chemistry, vol. 58, no. 6, 2010, pp. 3366-70.
Carvalho M, Silva BM, Silva R, et al. First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells. J Agric Food Chem. 2010;58(6):3366-70.
Carvalho, M., Silva, B. M., Silva, R., Valentão, P., Andrade, P. B., & Bastos, M. L. (2010). First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells. Journal of Agricultural and Food Chemistry, 58(6), 3366-70. https://doi.org/10.1021/jf903836k
Carvalho M, et al. First Report On Cydonia Oblonga Miller Anticancer Potential: Differential Antiproliferative Effect Against Human Kidney and Colon Cancer Cells. J Agric Food Chem. 2010 Mar 24;58(6):3366-70. PubMed PMID: 20192210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells. AU - Carvalho,Márcia, AU - Silva,Branca M, AU - Silva,Renata, AU - Valentão,Patrícia, AU - Andrade,Paula B, AU - Bastos,Maria L, PY - 2010/3/3/entrez PY - 2010/3/3/pubmed PY - 2010/7/16/medline SP - 3366 EP - 70 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 58 IS - 6 N2 - The present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC(50) = 239.7 +/- 43.2 microg/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 microg/mL). The antiproliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/20192210/First_report_on_Cydonia_oblonga_Miller_anticancer_potential:_differential_antiproliferative_effect_against_human_kidney_and_colon_cancer_cells_ L2 - https://doi.org/10.1021/jf903836k DB - PRIME DP - Unbound Medicine ER -