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Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study.
J Periodontol. 2010 Jul; 81(7):1056-63.JP

Abstract

BACKGROUND

The emergence of periodontal medicine has increased interest in defining the serologic profiles of inflammatory mediators in subjects with periodontitis. Thus, the aim of this pilot study is to evaluate the serum levels of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin (IL)-4, -17, and -23 in subjects with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) before and after non-surgical periodontal therapy.

METHODS

Cytokines were measured by enzyme-linked immunosorbent assay in serum samples taken from 42 systemically healthy subjects divided according to periodontal status into subjects with GAgP (n = 14) and GCP (n = 14) and periodontally healthy (PH) subjects (n = 14). In addition, the levels of cytokines were reassessed at 6 months after periodontal therapy in the periodontitis groups. Clinical parameters were also evaluated at baseline and 6 months post-therapy.

RESULTS

After therapy, both periodontitis groups demonstrated a significant improvement in clinical periodontal status (P <0.05). At baseline, concentrations of TNF-alpha (P = 0.0006) and IL-17 (P = 0.02) were significantly higher in the GAgP group compared to the other groups. There was a significant decrease in serum concentrations of TNF-alpha (P = 0.03) and IL-17 (P = 0.04) at 6 months post-therapy in the GAgP group (P <0.05). The concentration of TNF-alpha remained elevated in the GAgP group compared to the PH group at 6 months post-therapy (P = 0.04).

CONCLUSIONS

Subjects with GAgP presented higher levels of TNF-alpha and IL-17 than subjects with GCP and PH subjects. In addition, although the serum levels of these cytokines improved significantly as a result of periodontal therapy, the levels of TNF-alpha remained higher in subjects with GAgP compared to PH subjects.

Authors+Show Affiliations

Dental Research Division, Department of Periodontics, Guarulhos University, Guarulhos, São Paulo, Brazil. pduarte@ung.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20192617

Citation

Duarte, Poliana Mendes, et al. "Serum Levels of Cytokines in Subjects With Generalized Chronic and Aggressive Periodontitis Before and After Non-surgical Periodontal Therapy: a Pilot Study." Journal of Periodontology, vol. 81, no. 7, 2010, pp. 1056-63.
Duarte PM, da Rocha M, Sampaio E, et al. Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. J Periodontol. 2010;81(7):1056-63.
Duarte, P. M., da Rocha, M., Sampaio, E., Mestnik, M. J., Feres, M., Figueiredo, L. C., Bastos, M. F., & Faveri, M. (2010). Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. Journal of Periodontology, 81(7), 1056-63. https://doi.org/10.1902/jop.2010.090732
Duarte PM, et al. Serum Levels of Cytokines in Subjects With Generalized Chronic and Aggressive Periodontitis Before and After Non-surgical Periodontal Therapy: a Pilot Study. J Periodontol. 2010;81(7):1056-63. PubMed PMID: 20192617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. AU - Duarte,Poliana Mendes, AU - da Rocha,Marcelo, AU - Sampaio,Eduardo, AU - Mestnik,Maria Josefa, AU - Feres,Magda, AU - Figueiredo,Luciene Cristina, AU - Bastos,Marta Ferreira, AU - Faveri,Marcelo, PY - 2010/3/3/entrez PY - 2010/3/3/pubmed PY - 2010/10/1/medline SP - 1056 EP - 63 JF - Journal of periodontology JO - J. Periodontol. VL - 81 IS - 7 N2 - BACKGROUND: The emergence of periodontal medicine has increased interest in defining the serologic profiles of inflammatory mediators in subjects with periodontitis. Thus, the aim of this pilot study is to evaluate the serum levels of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin (IL)-4, -17, and -23 in subjects with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) before and after non-surgical periodontal therapy. METHODS: Cytokines were measured by enzyme-linked immunosorbent assay in serum samples taken from 42 systemically healthy subjects divided according to periodontal status into subjects with GAgP (n = 14) and GCP (n = 14) and periodontally healthy (PH) subjects (n = 14). In addition, the levels of cytokines were reassessed at 6 months after periodontal therapy in the periodontitis groups. Clinical parameters were also evaluated at baseline and 6 months post-therapy. RESULTS: After therapy, both periodontitis groups demonstrated a significant improvement in clinical periodontal status (P <0.05). At baseline, concentrations of TNF-alpha (P = 0.0006) and IL-17 (P = 0.02) were significantly higher in the GAgP group compared to the other groups. There was a significant decrease in serum concentrations of TNF-alpha (P = 0.03) and IL-17 (P = 0.04) at 6 months post-therapy in the GAgP group (P <0.05). The concentration of TNF-alpha remained elevated in the GAgP group compared to the PH group at 6 months post-therapy (P = 0.04). CONCLUSIONS: Subjects with GAgP presented higher levels of TNF-alpha and IL-17 than subjects with GCP and PH subjects. In addition, although the serum levels of these cytokines improved significantly as a result of periodontal therapy, the levels of TNF-alpha remained higher in subjects with GAgP compared to PH subjects. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/20192617/Serum_levels_of_cytokines_in_subjects_with_generalized_chronic_and_aggressive_periodontitis_before_and_after_non_surgical_periodontal_therapy:_a_pilot_study_ L2 - https://doi.org/10.1902/jop.2010.090732 DB - PRIME DP - Unbound Medicine ER -